Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics
Over the past decade, more interests have been aroused in engineering protein-based nanoformulations for cancer treatment. This excitement originates from the success of FDA approved Abraxane (Albumin-based paclitaxel nanoparticles) in 2005. The new generation of biocompatible endogenous protein-bas...
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doaj-4147920cc6684c3c904bc463c9eceff92020-11-24T23:24:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-04-01910.3389/fphar.2018.00421367412Bio-Inspired Protein-Based Nanoformulations for Cancer TheranosticsYi Gou0Dandan Miao1Min Zhou2Lijuan Wang3Hongyu Zhou4Gaoxing Su5Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Targets, School of Pharmacy, Nantong University, Nantong, ChinaJiangsu Province Key Laboratory of Inflammation and Molecular Drug Targets, School of Pharmacy, Nantong University, Nantong, ChinaJiangsu Province Key Laboratory of Inflammation and Molecular Drug Targets, School of Pharmacy, Nantong University, Nantong, ChinaGuangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, ChinaGuangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, ChinaJiangsu Province Key Laboratory of Inflammation and Molecular Drug Targets, School of Pharmacy, Nantong University, Nantong, ChinaOver the past decade, more interests have been aroused in engineering protein-based nanoformulations for cancer treatment. This excitement originates from the success of FDA approved Abraxane (Albumin-based paclitaxel nanoparticles) in 2005. The new generation of biocompatible endogenous protein-based nanoformulations is currently constructed through delivering cancer therapeutic and diagnostic agents simultaneously, as named potential theranostics. Protein nanoformulations are commonly incorporated with dyes, contrast agents, drug payloads or inorganic nanoclusters, serving as imaging-guided combinatorial cancer therapeutics. Employing the nature identity of proteins, the theranostics, escape the clearance by reticuloendothelial cells and have a long blood circulation time. The nanoscale sizet allows them to be penetrated deeply into tumor tissues. In addition, stimuli release and targeted molecules are incorporated to improve the delivery efficiency. The ongoing advancement of protein-based nanoformulations for cancer theranostics in recent 5 years is reviewed in this paper. Fine-designed nanoformulations based on albumin, ferritin, gelatin, and transferrin are highlighted from the literature. Finally, the current challenges are identified in translating protein-based nanoformulations from laboratory to clinical trials.http://journal.frontiersin.org/article/10.3389/fphar.2018.00421/fullprotein nanoparticlescancer therapeuticstheranosticsdrug deliverycancer diagnostics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi Gou Dandan Miao Min Zhou Lijuan Wang Hongyu Zhou Gaoxing Su |
spellingShingle |
Yi Gou Dandan Miao Min Zhou Lijuan Wang Hongyu Zhou Gaoxing Su Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics Frontiers in Pharmacology protein nanoparticles cancer therapeutics theranostics drug delivery cancer diagnostics |
author_facet |
Yi Gou Dandan Miao Min Zhou Lijuan Wang Hongyu Zhou Gaoxing Su |
author_sort |
Yi Gou |
title |
Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics |
title_short |
Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics |
title_full |
Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics |
title_fullStr |
Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics |
title_full_unstemmed |
Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics |
title_sort |
bio-inspired protein-based nanoformulations for cancer theranostics |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2018-04-01 |
description |
Over the past decade, more interests have been aroused in engineering protein-based nanoformulations for cancer treatment. This excitement originates from the success of FDA approved Abraxane (Albumin-based paclitaxel nanoparticles) in 2005. The new generation of biocompatible endogenous protein-based nanoformulations is currently constructed through delivering cancer therapeutic and diagnostic agents simultaneously, as named potential theranostics. Protein nanoformulations are commonly incorporated with dyes, contrast agents, drug payloads or inorganic nanoclusters, serving as imaging-guided combinatorial cancer therapeutics. Employing the nature identity of proteins, the theranostics, escape the clearance by reticuloendothelial cells and have a long blood circulation time. The nanoscale sizet allows them to be penetrated deeply into tumor tissues. In addition, stimuli release and targeted molecules are incorporated to improve the delivery efficiency. The ongoing advancement of protein-based nanoformulations for cancer theranostics in recent 5 years is reviewed in this paper. Fine-designed nanoformulations based on albumin, ferritin, gelatin, and transferrin are highlighted from the literature. Finally, the current challenges are identified in translating protein-based nanoformulations from laboratory to clinical trials. |
topic |
protein nanoparticles cancer therapeutics theranostics drug delivery cancer diagnostics |
url |
http://journal.frontiersin.org/article/10.3389/fphar.2018.00421/full |
work_keys_str_mv |
AT yigou bioinspiredproteinbasednanoformulationsforcancertheranostics AT dandanmiao bioinspiredproteinbasednanoformulationsforcancertheranostics AT minzhou bioinspiredproteinbasednanoformulationsforcancertheranostics AT lijuanwang bioinspiredproteinbasednanoformulationsforcancertheranostics AT hongyuzhou bioinspiredproteinbasednanoformulationsforcancertheranostics AT gaoxingsu bioinspiredproteinbasednanoformulationsforcancertheranostics |
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1725561365948530688 |