Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators.
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5135050?pdf=render |
id |
doaj-4164e987716840e5ade787add8a08a56 |
---|---|
record_format |
Article |
spelling |
doaj-4164e987716840e5ade787add8a08a562020-11-25T01:42:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016668710.1371/journal.pone.0166687Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators.Vinicius Coneglian SantosAna Paula Renno SierraRodrigo OliveiraKim Guimarães CaçulaCésar Miguel MomessoFabio Takeo SatoMaysa Braga Barros SilvaHeloisa Helena OliveiraMaria Elizabeth Pereira PassosDiego Ribeiro de SouzaOlivia Santos GondimMarino BenettiAdriana Cristina Levada-PiresNabil GhorayebMaria Augusta Peduti Dal Molin KissRenata GorjãoTânia Cristina Pithon-CuriMaria Fernanda Cury-BoaventuraThe fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the "open-window" post-exercise hypothesis.http://europepmc.org/articles/PMC5135050?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vinicius Coneglian Santos Ana Paula Renno Sierra Rodrigo Oliveira Kim Guimarães Caçula César Miguel Momesso Fabio Takeo Sato Maysa Braga Barros Silva Heloisa Helena Oliveira Maria Elizabeth Pereira Passos Diego Ribeiro de Souza Olivia Santos Gondim Marino Benetti Adriana Cristina Levada-Pires Nabil Ghorayeb Maria Augusta Peduti Dal Molin Kiss Renata Gorjão Tânia Cristina Pithon-Curi Maria Fernanda Cury-Boaventura |
spellingShingle |
Vinicius Coneglian Santos Ana Paula Renno Sierra Rodrigo Oliveira Kim Guimarães Caçula César Miguel Momesso Fabio Takeo Sato Maysa Braga Barros Silva Heloisa Helena Oliveira Maria Elizabeth Pereira Passos Diego Ribeiro de Souza Olivia Santos Gondim Marino Benetti Adriana Cristina Levada-Pires Nabil Ghorayeb Maria Augusta Peduti Dal Molin Kiss Renata Gorjão Tânia Cristina Pithon-Curi Maria Fernanda Cury-Boaventura Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators. PLoS ONE |
author_facet |
Vinicius Coneglian Santos Ana Paula Renno Sierra Rodrigo Oliveira Kim Guimarães Caçula César Miguel Momesso Fabio Takeo Sato Maysa Braga Barros Silva Heloisa Helena Oliveira Maria Elizabeth Pereira Passos Diego Ribeiro de Souza Olivia Santos Gondim Marino Benetti Adriana Cristina Levada-Pires Nabil Ghorayeb Maria Augusta Peduti Dal Molin Kiss Renata Gorjão Tânia Cristina Pithon-Curi Maria Fernanda Cury-Boaventura |
author_sort |
Vinicius Coneglian Santos |
title |
Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators. |
title_short |
Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators. |
title_full |
Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators. |
title_fullStr |
Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators. |
title_full_unstemmed |
Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators. |
title_sort |
marathon race affects neutrophil surface molecules: role of inflammatory mediators. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the "open-window" post-exercise hypothesis. |
url |
http://europepmc.org/articles/PMC5135050?pdf=render |
work_keys_str_mv |
AT viniciusconegliansantos marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT anapaularennosierra marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT rodrigooliveira marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT kimguimaraescacula marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT cesarmiguelmomesso marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT fabiotakeosato marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT maysabragabarrossilva marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT heloisahelenaoliveira marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT mariaelizabethpereirapassos marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT diegoribeirodesouza marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT oliviasantosgondim marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT marinobenetti marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT adrianacristinalevadapires marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT nabilghorayeb marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT mariaaugustapedutidalmolinkiss marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT renatagorjao marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT taniacristinapithoncuri marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators AT mariafernandacuryboaventura marathonraceaffectsneutrophilsurfacemoleculesroleofinflammatorymediators |
_version_ |
1725036902387548160 |