3D Exploration of the Brainstem in 50-Micron Resolution MRI
The brainstem, a structure of vital importance in mammals, is currently becoming a principal focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary structures serve as the conduit for signals between the forebrain and spinal cord, are the epicenter of cranial nerve...
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Format: | Article |
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Frontiers Media S.A.
2020-09-01
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Series: | Frontiers in Neuroanatomy |
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Online Access: | https://www.frontiersin.org/article/10.3389/fnana.2020.00040/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Richard Jarrett Rushmore Richard Jarrett Rushmore Richard Jarrett Rushmore Peter Wilson-Braun Peter Wilson-Braun George Papadimitriou Isaac Ng Yogesh Rathi Yogesh Rathi Fan Zhang Fan Zhang Fan Zhang Lauren Jean O’Donnell Lauren Jean O’Donnell Lauren Jean O’Donnell Marek Kubicki Marek Kubicki Marek Kubicki Sylvain Bouix Edward Yeterian Jean-Jacques Lemaire Evan Calabrese G. Allan Johnson Ron Kikinis Ron Kikinis Ron Kikinis Nikos Makris Nikos Makris Nikos Makris Nikos Makris |
spellingShingle |
Richard Jarrett Rushmore Richard Jarrett Rushmore Richard Jarrett Rushmore Peter Wilson-Braun Peter Wilson-Braun George Papadimitriou Isaac Ng Yogesh Rathi Yogesh Rathi Fan Zhang Fan Zhang Fan Zhang Lauren Jean O’Donnell Lauren Jean O’Donnell Lauren Jean O’Donnell Marek Kubicki Marek Kubicki Marek Kubicki Sylvain Bouix Edward Yeterian Jean-Jacques Lemaire Evan Calabrese G. Allan Johnson Ron Kikinis Ron Kikinis Ron Kikinis Nikos Makris Nikos Makris Nikos Makris Nikos Makris 3D Exploration of the Brainstem in 50-Micron Resolution MRI Frontiers in Neuroanatomy ultrahigh-resolution MRI human brainstem anatomy neuroimaging ontology terminologia anatomica brainstem atlas |
author_facet |
Richard Jarrett Rushmore Richard Jarrett Rushmore Richard Jarrett Rushmore Peter Wilson-Braun Peter Wilson-Braun George Papadimitriou Isaac Ng Yogesh Rathi Yogesh Rathi Fan Zhang Fan Zhang Fan Zhang Lauren Jean O’Donnell Lauren Jean O’Donnell Lauren Jean O’Donnell Marek Kubicki Marek Kubicki Marek Kubicki Sylvain Bouix Edward Yeterian Jean-Jacques Lemaire Evan Calabrese G. Allan Johnson Ron Kikinis Ron Kikinis Ron Kikinis Nikos Makris Nikos Makris Nikos Makris Nikos Makris |
author_sort |
Richard Jarrett Rushmore |
title |
3D Exploration of the Brainstem in 50-Micron Resolution MRI |
title_short |
3D Exploration of the Brainstem in 50-Micron Resolution MRI |
title_full |
3D Exploration of the Brainstem in 50-Micron Resolution MRI |
title_fullStr |
3D Exploration of the Brainstem in 50-Micron Resolution MRI |
title_full_unstemmed |
3D Exploration of the Brainstem in 50-Micron Resolution MRI |
title_sort |
3d exploration of the brainstem in 50-micron resolution mri |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroanatomy |
issn |
1662-5129 |
publishDate |
2020-09-01 |
description |
The brainstem, a structure of vital importance in mammals, is currently becoming a principal focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary structures serve as the conduit for signals between the forebrain and spinal cord, are the epicenter of cranial nerve-circuits and systems, and subserve such integrative functions as consciousness, emotional processing, pain, and motivation. In this study, we parcellated the nuclear masses and the principal fiber pathways that were visible in a high-resolution T2-weighted MRI dataset of 50-micron isotropic voxels of a postmortem human brainstem. Based on this analysis, we generated a detailed map of the human brainstem. To assess the validity of our maps, we compared our observations with histological maps of traditional human brainstem atlases. Given the unique capability of MRI-based morphometric analysis in generating and preserving the morphology of 3D objects from individual 2D sections, we reconstructed the motor, sensory and integrative neural systems of the brainstem and rendered them in 3D representations. We anticipate the utilization of these maps by the neuroimaging community for applications in basic neuroscience as well as in neurology, psychiatry, and neurosurgery, due to their versatile computational nature in 2D and 3D representations in a publicly available capacity. |
topic |
ultrahigh-resolution MRI human brainstem anatomy neuroimaging ontology terminologia anatomica brainstem atlas |
url |
https://www.frontiersin.org/article/10.3389/fnana.2020.00040/full |
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doaj-416b4ec5e1c0407cac3100fc02965d722020-11-25T03:40:09ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292020-09-011410.3389/fnana.2020.000405509383D Exploration of the Brainstem in 50-Micron Resolution MRIRichard Jarrett Rushmore0Richard Jarrett Rushmore1Richard Jarrett Rushmore2Peter Wilson-Braun3Peter Wilson-Braun4George Papadimitriou5Isaac Ng6Yogesh Rathi7Yogesh Rathi8Fan Zhang9Fan Zhang10Fan Zhang11Lauren Jean O’Donnell12Lauren Jean O’Donnell13Lauren Jean O’Donnell14Marek Kubicki15Marek Kubicki16Marek Kubicki17Sylvain Bouix18Edward Yeterian19Jean-Jacques Lemaire20Evan Calabrese21G. Allan Johnson22Ron Kikinis23Ron Kikinis24Ron Kikinis25Nikos Makris26Nikos Makris27Nikos Makris28Nikos Makris29Departments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesPsychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United StatesDepartments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesPsychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United StatesDepartments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesDepartments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesDepartments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesPsychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesLaboratory for Mathematics and Imaging, Brigham and Women’s Hospital, Boston, MA, United StatesSurgical Planning Laboratory, Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesLaboratory for Mathematics and Imaging, Brigham and Women’s Hospital, Boston, MA, United StatesSurgical Planning Laboratory, Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United StatesDepartments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesPsychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesPsychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Psychology, Colby College, Waterville, ME, United StatesService de Neurochirurgie, CHU Clermont-Ferrand, Universite Clermont Auvergne, CNRS, SIGMA Clermont, Clermont-Ferrand, FranceDepartment of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United StatesDepartment of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesSurgical Planning Laboratory, Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States0Computer Science Department, University of Bremen, Institutsleiter, Fraunhofer MEVIS, Bremen, GermanyDepartments of Psychiatry and Neurology, Center for Morphometric Analysis, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesPsychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, United StatesDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesThe brainstem, a structure of vital importance in mammals, is currently becoming a principal focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary structures serve as the conduit for signals between the forebrain and spinal cord, are the epicenter of cranial nerve-circuits and systems, and subserve such integrative functions as consciousness, emotional processing, pain, and motivation. In this study, we parcellated the nuclear masses and the principal fiber pathways that were visible in a high-resolution T2-weighted MRI dataset of 50-micron isotropic voxels of a postmortem human brainstem. Based on this analysis, we generated a detailed map of the human brainstem. To assess the validity of our maps, we compared our observations with histological maps of traditional human brainstem atlases. Given the unique capability of MRI-based morphometric analysis in generating and preserving the morphology of 3D objects from individual 2D sections, we reconstructed the motor, sensory and integrative neural systems of the brainstem and rendered them in 3D representations. We anticipate the utilization of these maps by the neuroimaging community for applications in basic neuroscience as well as in neurology, psychiatry, and neurosurgery, due to their versatile computational nature in 2D and 3D representations in a publicly available capacity.https://www.frontiersin.org/article/10.3389/fnana.2020.00040/fullultrahigh-resolution MRIhuman brainstem anatomyneuroimagingontologyterminologia anatomicabrainstem atlas |