Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis
Background: Diffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflamm...
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doaj-4176a039c2ee472290c179a28f1d026b2021-07-23T13:49:34ZengMDPI AGJournal of Personalized Medicine2075-44262021-07-011166366310.3390/jpm11070663Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal HyperostosisNetanja I. Harlianto0Jan Westerink1Wouter Foppen2Marjolein E. Hol3Rianne Wittenberg4Pieternella H. van der Veen5Bram van Ginneken6Jonneke S. Kuperus7Jorrit-Jan Verlaan8Pim A. de Jong9Firdaus A. A. Mohamed Hoesein10on behalf of the UCC-SMART-Study GroupDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Vascular Medicine, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, Netherlands Cancer Institute, 1066 CX Amsterdam, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsBackground: Diffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflammation in the development of DISH. Methods: In 4334 patients with manifest vascular disease, the relation between different adiposity measures and the presence of DISH was compared using <i>z</i>-scores via standard deviation logistic regression analyses. Analyses were stratified by sex and adjusted for age, systolic blood pressure, diabetes, non-HDL cholesterol, smoking status, and renal function. Results: DISH was present in 391 (9%) subjects. The presence of DISH was associated with markers of adiposity and had a strong relation with VAT in males (OR: 1.35; 95%CI: 1.20–1.54) and females (OR: 1.43; 95%CI: 1.06–1.93). In males with the most severe DISH (extensive ossification of seven or more vertebral bodies) the association between DISH and VAT was stronger (OR: 1.61; 95%CI: 1.31–1.98), while increased subcutaneous fat was negatively associated with DISH (OR: 0.65; 95%CI: 0.49–0.95). In females, increased subcutaneous fat was associated with the presence of DISH (OR: 1.43; 95%CI: 1.14–1.80). Conclusion: Markers of adiposity, including VAT, are strongly associated with the presence of DISH. Subcutaneous adipose tissue thickness was negatively associated with more severe cases of DISH in males, while in females, increased subcutaneous adipose tissue was associated with the presence of DISH.https://www.mdpi.com/2075-4426/11/7/663diffuse idiopathic skeletal hyperostosisrisk factorsadiposityintra-abdominal fat |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Netanja I. Harlianto Jan Westerink Wouter Foppen Marjolein E. Hol Rianne Wittenberg Pieternella H. van der Veen Bram van Ginneken Jonneke S. Kuperus Jorrit-Jan Verlaan Pim A. de Jong Firdaus A. A. Mohamed Hoesein on behalf of the UCC-SMART-Study Group |
spellingShingle |
Netanja I. Harlianto Jan Westerink Wouter Foppen Marjolein E. Hol Rianne Wittenberg Pieternella H. van der Veen Bram van Ginneken Jonneke S. Kuperus Jorrit-Jan Verlaan Pim A. de Jong Firdaus A. A. Mohamed Hoesein on behalf of the UCC-SMART-Study Group Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis Journal of Personalized Medicine diffuse idiopathic skeletal hyperostosis risk factors adiposity intra-abdominal fat |
author_facet |
Netanja I. Harlianto Jan Westerink Wouter Foppen Marjolein E. Hol Rianne Wittenberg Pieternella H. van der Veen Bram van Ginneken Jonneke S. Kuperus Jorrit-Jan Verlaan Pim A. de Jong Firdaus A. A. Mohamed Hoesein on behalf of the UCC-SMART-Study Group |
author_sort |
Netanja I. Harlianto |
title |
Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis |
title_short |
Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis |
title_full |
Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis |
title_fullStr |
Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis |
title_full_unstemmed |
Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis |
title_sort |
visceral adipose tissue and different measures of adiposity in different severities of diffuse idiopathic skeletal hyperostosis |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2021-07-01 |
description |
Background: Diffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflammation in the development of DISH. Methods: In 4334 patients with manifest vascular disease, the relation between different adiposity measures and the presence of DISH was compared using <i>z</i>-scores via standard deviation logistic regression analyses. Analyses were stratified by sex and adjusted for age, systolic blood pressure, diabetes, non-HDL cholesterol, smoking status, and renal function. Results: DISH was present in 391 (9%) subjects. The presence of DISH was associated with markers of adiposity and had a strong relation with VAT in males (OR: 1.35; 95%CI: 1.20–1.54) and females (OR: 1.43; 95%CI: 1.06–1.93). In males with the most severe DISH (extensive ossification of seven or more vertebral bodies) the association between DISH and VAT was stronger (OR: 1.61; 95%CI: 1.31–1.98), while increased subcutaneous fat was negatively associated with DISH (OR: 0.65; 95%CI: 0.49–0.95). In females, increased subcutaneous fat was associated with the presence of DISH (OR: 1.43; 95%CI: 1.14–1.80). Conclusion: Markers of adiposity, including VAT, are strongly associated with the presence of DISH. Subcutaneous adipose tissue thickness was negatively associated with more severe cases of DISH in males, while in females, increased subcutaneous adipose tissue was associated with the presence of DISH. |
topic |
diffuse idiopathic skeletal hyperostosis risk factors adiposity intra-abdominal fat |
url |
https://www.mdpi.com/2075-4426/11/7/663 |
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