Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data
Decision making is a complex cognitive phenomenon commonly used in everyday life. Studies have shown differences in behavioral strategies in risky decision-making tasks over the course of aging. The development of functional neuroimaging has gradually allowed the exploration of the neurofunctional b...
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doaj-418c7882ae964cb0a251accd2f7c44b22021-08-26T13:34:38ZengMDPI AGBrain Sciences2076-34252021-08-01111043104310.3390/brainsci11081043Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI DataThomas Tannou0Eloi Magnin1Alexandre Comte2Régis Aubry3Sven Joubert4Laboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive—UR LINC, UFC, UBFC, 25000 Besançon, FranceLaboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive—UR LINC, UFC, UBFC, 25000 Besançon, FranceLaboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive—UR LINC, UFC, UBFC, 25000 Besançon, FranceLaboratoire de Recherches Intégratives en Neurosciences et Psychologie Cognitive—UR LINC, UFC, UBFC, 25000 Besançon, FranceCentre de Recherche Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Montréal, QC H3W 1W6, CanadaDecision making is a complex cognitive phenomenon commonly used in everyday life. Studies have shown differences in behavioral strategies in risky decision-making tasks over the course of aging. The development of functional neuroimaging has gradually allowed the exploration of the neurofunctional bases of these behaviors. The purpose of our study was to carry out a meta-analysis on the neural networks underlying risky decision making in healthy older adults. Following the PRISMA guidelines, we systematically searched for fMRI studies of decision making in older adults using risky decision-making tasks. To perform the quantitative meta-analysis, we used the revised version of the activation likelihood estimation (ALE) algorithm. A total of 620 references were selected for initial screening. Among these, five studies with a total of 98 cognitively normal older participants (mean age: 69.5 years) were included. The meta-analysis yielded two clusters. Main activations were found in the right insula, bilateral dorsolateral prefrontal cortex (dlPFC) and left orbitofrontal cortex (OFC). Despite the limited number of studies included, our meta-analysis highlights the crucial involvement of circuits associated with both emotion regulation and the decision to act. However, in contrast to the literature on young adults, our results indicate a different pattern of hemispheric lateralization in older participants. These activations can be used as a minimum pattern of activation in the risky decision-making tasks of healthy older subjects.https://www.mdpi.com/2076-3425/11/8/1043agingdecision makingfMRImeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Tannou Eloi Magnin Alexandre Comte Régis Aubry Sven Joubert |
spellingShingle |
Thomas Tannou Eloi Magnin Alexandre Comte Régis Aubry Sven Joubert Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data Brain Sciences aging decision making fMRI meta-analysis |
author_facet |
Thomas Tannou Eloi Magnin Alexandre Comte Régis Aubry Sven Joubert |
author_sort |
Thomas Tannou |
title |
Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data |
title_short |
Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data |
title_full |
Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data |
title_fullStr |
Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data |
title_full_unstemmed |
Neural Activation in Risky Decision-Making Tasks in Healthy Older Adults: A Meta-Analysis of fMRI Data |
title_sort |
neural activation in risky decision-making tasks in healthy older adults: a meta-analysis of fmri data |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-08-01 |
description |
Decision making is a complex cognitive phenomenon commonly used in everyday life. Studies have shown differences in behavioral strategies in risky decision-making tasks over the course of aging. The development of functional neuroimaging has gradually allowed the exploration of the neurofunctional bases of these behaviors. The purpose of our study was to carry out a meta-analysis on the neural networks underlying risky decision making in healthy older adults. Following the PRISMA guidelines, we systematically searched for fMRI studies of decision making in older adults using risky decision-making tasks. To perform the quantitative meta-analysis, we used the revised version of the activation likelihood estimation (ALE) algorithm. A total of 620 references were selected for initial screening. Among these, five studies with a total of 98 cognitively normal older participants (mean age: 69.5 years) were included. The meta-analysis yielded two clusters. Main activations were found in the right insula, bilateral dorsolateral prefrontal cortex (dlPFC) and left orbitofrontal cortex (OFC). Despite the limited number of studies included, our meta-analysis highlights the crucial involvement of circuits associated with both emotion regulation and the decision to act. However, in contrast to the literature on young adults, our results indicate a different pattern of hemispheric lateralization in older participants. These activations can be used as a minimum pattern of activation in the risky decision-making tasks of healthy older subjects. |
topic |
aging decision making fMRI meta-analysis |
url |
https://www.mdpi.com/2076-3425/11/8/1043 |
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