Synthesis and biocidal activity of modified poly(vinyl alcohol)
Functionalized polymers and their polymer nature give them more advantages than the corresponding small molecules. In this respect, polymeric ammonium and phosphonium salts were prepared by chemical modifications of poly(vinyl alcohol) (PVA) aiming to explore their antimicrobial activities against p...
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doaj-419d268be1f247d4bb4ae42de7eea1672020-11-25T00:29:55ZengElsevierArabian Journal of Chemistry1878-53522014-07-017335536110.1016/j.arabjc.2013.04.005Synthesis and biocidal activity of modified poly(vinyl alcohol)El-Refaie Kenawy0Mohamed H. El-Newehy1Fouad I. Abdel-Hay2Abd El-Raheem R. El-Shanshoury3Polymer Research Group, Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, EgyptPolymer Research Group, Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, EgyptPolymer Research Group, Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, EgyptDepartment of Biotechnology, Faculty of Science, Taif University, Taif 21974, Saudi ArabiaFunctionalized polymers and their polymer nature give them more advantages than the corresponding small molecules. In this respect, polymeric ammonium and phosphonium salts were prepared by chemical modifications of poly(vinyl alcohol) (PVA) aiming to explore their antimicrobial activities against pathogenic bacteria and fungi. The modifications were performed by chloroacetylation with chloroacetyl chloride. Incorporation of the ammonium and phosphonium salts was conducted by the reaction of chloroacetylated poly(vinyl alcohol) (CPVA) with triethylamine (TEA), triphenylphosphine (TPP), and tributylphosphine (TBP). The antimicrobial activity of the polymers against variety of test microorganisms was examined by the cut plug and viable cell counting methods of shake cultures of 10 times dilute nutrient broth and Sabouraud’s media, seeded with the test microorganisms. It was found that the immobilized polymers exhibited antimicrobial activity against the Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Shigella sp. and Salmonella typhi) and Gram positive bacteria (Bacillus subtilis and B. cereus) and the dermatophyte fungus (Trichophyton rubrum). The growth inhibition of the test microorganisms (ratio of surviving cell number, M/C) varied according to the composition of the active group in the polymer and the test organism. It increased by increasing the concentration of the polymer. Triphenyl phosphonium salt of the modified poly(vinyl alcohol) exhibited the most biocidal activity against both Gram-negative and Gram-positive bacteria after 24 h.http://www.sciencedirect.com/science/article/pii/S1878535213000944Onium saltsPolycationic biocidesAntimicrobial activityPoly(vinyl alcohol) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
El-Refaie Kenawy Mohamed H. El-Newehy Fouad I. Abdel-Hay Abd El-Raheem R. El-Shanshoury |
spellingShingle |
El-Refaie Kenawy Mohamed H. El-Newehy Fouad I. Abdel-Hay Abd El-Raheem R. El-Shanshoury Synthesis and biocidal activity of modified poly(vinyl alcohol) Arabian Journal of Chemistry Onium salts Polycationic biocides Antimicrobial activity Poly(vinyl alcohol) |
author_facet |
El-Refaie Kenawy Mohamed H. El-Newehy Fouad I. Abdel-Hay Abd El-Raheem R. El-Shanshoury |
author_sort |
El-Refaie Kenawy |
title |
Synthesis and biocidal activity of modified poly(vinyl alcohol) |
title_short |
Synthesis and biocidal activity of modified poly(vinyl alcohol) |
title_full |
Synthesis and biocidal activity of modified poly(vinyl alcohol) |
title_fullStr |
Synthesis and biocidal activity of modified poly(vinyl alcohol) |
title_full_unstemmed |
Synthesis and biocidal activity of modified poly(vinyl alcohol) |
title_sort |
synthesis and biocidal activity of modified poly(vinyl alcohol) |
publisher |
Elsevier |
series |
Arabian Journal of Chemistry |
issn |
1878-5352 |
publishDate |
2014-07-01 |
description |
Functionalized polymers and their polymer nature give them more advantages than the corresponding small molecules. In this respect, polymeric ammonium and phosphonium salts were prepared by chemical modifications of poly(vinyl alcohol) (PVA) aiming to explore their antimicrobial activities against pathogenic bacteria and fungi. The modifications were performed by chloroacetylation with chloroacetyl chloride. Incorporation of the ammonium and phosphonium salts was conducted by the reaction of chloroacetylated poly(vinyl alcohol) (CPVA) with triethylamine (TEA), triphenylphosphine (TPP), and tributylphosphine (TBP). The antimicrobial activity of the polymers against variety of test microorganisms was examined by the cut plug and viable cell counting methods of shake cultures of 10 times dilute nutrient broth and Sabouraud’s media, seeded with the test microorganisms. It was found that the immobilized polymers exhibited antimicrobial activity against the Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Shigella sp. and Salmonella typhi) and Gram positive bacteria (Bacillus subtilis and B. cereus) and the dermatophyte fungus (Trichophyton rubrum). The growth inhibition of the test microorganisms (ratio of surviving cell number, M/C) varied according to the composition of the active group in the polymer and the test organism. It increased by increasing the concentration of the polymer. Triphenyl phosphonium salt of the modified poly(vinyl alcohol) exhibited the most biocidal activity against both Gram-negative and Gram-positive bacteria after 24 h. |
topic |
Onium salts Polycationic biocides Antimicrobial activity Poly(vinyl alcohol) |
url |
http://www.sciencedirect.com/science/article/pii/S1878535213000944 |
work_keys_str_mv |
AT elrefaiekenawy synthesisandbiocidalactivityofmodifiedpolyvinylalcohol AT mohamedhelnewehy synthesisandbiocidalactivityofmodifiedpolyvinylalcohol AT fouadiabdelhay synthesisandbiocidalactivityofmodifiedpolyvinylalcohol AT abdelraheemrelshanshoury synthesisandbiocidalactivityofmodifiedpolyvinylalcohol |
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