Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments
Hepatic diseases are a major problem of worldwide proportions, and liver damage is very common since the liver has to encounter several toxic substances during their metabolism. Pollution is also one of the major causes of hepatic dysfunctioning, high level of pollutant in blood enhances the risk fo...
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doaj-41a4440608324219a7a29ae7d0710ae42020-11-25T01:15:22ZengWolters Kluwer Medknow PublicationsEnvironmental Disease2468-56902468-57042017-01-0123879410.4103/ed.ed_12_17Ursolic acid: A natural preventive aesculapian for environmental hepatic ailmentsGunja SrivastavaManjul Pratap SinghAnurag MishraHepatic diseases are a major problem of worldwide proportions, and liver damage is very common since the liver has to encounter several toxic substances during their metabolism. Pollution is also one of the major causes of hepatic dysfunctioning, high level of pollutant in blood enhances the risk for abnormal liver enzyme level. Increased industrialization has prone workers to confront the several harmful chemicals in their day-to-day life that affect liver adversely; several studies have been published in the evidence of this fact; people cannot avoid their exposure to such environmental conditions but can counter with its harmful effects. Thus, to overcome this loophole, there is a demand of such agents that has the capability to fight against such toxins and pollutants. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, has established its identity as a very potent hepatoprotective agent in recent years. It is one of the strongest natural healers that are present in several medicinal plants. Its antioxidant effect makes it a potent antihepatotoxic agent as it modulates mitogen-activated protein kinases and nuclear factor-kappa B signaling pathway. UA has anticholestatic property that enhances its effectiveness somewhere equal to or in some cases better than silymarin (a well-known potent hepatoprotective agent). In recent years, it has attracted considerable attention due to its double-edged sword effect on the liver, defined in terms of prevention and cures both.http://www.environmentmed.org/article.asp?issn=2468-5690;year=2017;volume=2;issue=3;spage=87;epage=94;aulast=SrivastavaAntihepatotoxicantioxidanthepatoprotectivehepatotoxicityhigh performance thin-layer chromatographylivertriterpenoidsursolic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gunja Srivastava Manjul Pratap Singh Anurag Mishra |
spellingShingle |
Gunja Srivastava Manjul Pratap Singh Anurag Mishra Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments Environmental Disease Antihepatotoxic antioxidant hepatoprotective hepatotoxicity high performance thin-layer chromatography liver triterpenoids ursolic acid |
author_facet |
Gunja Srivastava Manjul Pratap Singh Anurag Mishra |
author_sort |
Gunja Srivastava |
title |
Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments |
title_short |
Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments |
title_full |
Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments |
title_fullStr |
Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments |
title_full_unstemmed |
Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments |
title_sort |
ursolic acid: a natural preventive aesculapian for environmental hepatic ailments |
publisher |
Wolters Kluwer Medknow Publications |
series |
Environmental Disease |
issn |
2468-5690 2468-5704 |
publishDate |
2017-01-01 |
description |
Hepatic diseases are a major problem of worldwide proportions, and liver damage is very common since the liver has to encounter several toxic substances during their metabolism. Pollution is also one of the major causes of hepatic dysfunctioning, high level of pollutant in blood enhances the risk for abnormal liver enzyme level. Increased industrialization has prone workers to confront the several harmful chemicals in their day-to-day life that affect liver adversely; several studies have been published in the evidence of this fact; people cannot avoid their exposure to such environmental conditions but can counter with its harmful effects. Thus, to overcome this loophole, there is a demand of such agents that has the capability to fight against such toxins and pollutants. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, has established its identity as a very potent hepatoprotective agent in recent years. It is one of the strongest natural healers that are present in several medicinal plants. Its antioxidant effect makes it a potent antihepatotoxic agent as it modulates mitogen-activated protein kinases and nuclear factor-kappa B signaling pathway. UA has anticholestatic property that enhances its effectiveness somewhere equal to or in some cases better than silymarin (a well-known potent hepatoprotective agent). In recent years, it has attracted considerable attention due to its double-edged sword effect on the liver, defined in terms of prevention and cures both. |
topic |
Antihepatotoxic antioxidant hepatoprotective hepatotoxicity high performance thin-layer chromatography liver triterpenoids ursolic acid |
url |
http://www.environmentmed.org/article.asp?issn=2468-5690;year=2017;volume=2;issue=3;spage=87;epage=94;aulast=Srivastava |
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