Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab

Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab

Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an...

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Bibliographic Details
Main Authors: Deirdre Nolfi-Donegan, Monica Konar, Vianca Vianzon, Jessica MacNeil, James Cooper, Perrianne Lurie, Judi Sedivy, Xin Wang, Dan M. Granoff, Lucy McNamara
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2018-08-01
Series:Emerging Infectious Diseases
Subjects:
paroxysmal nocturnal hemoglobinuria
MenB-4C
4CMenB
Bexsero
Soliris
eculizumab
Online Access:https://wwwnc.cdc.gov/eid/article/24/8/18-0228_article
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spelling doaj-41a58f4f56f648ff9aee5cb31d2af7d62020-11-24T23:07:52ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-08-012481561156410.3201/eid2408.180228Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving EculizumabDeirdre Nolfi-DoneganMonica KonarVianca VianzonJessica MacNeilJames CooperPerrianne LurieJudi SedivyXin WangDan M. GranoffLucy McNamaraPatients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.https://wwwnc.cdc.gov/eid/article/24/8/18-0228_articleparoxysmal nocturnal hemoglobinuriaMenB-4C4CMenBBexseroSoliriseculizumab
collection DOAJ
language English
format Article
sources DOAJ
author Deirdre Nolfi-Donegan
Monica Konar
Vianca Vianzon
Jessica MacNeil
James Cooper
Perrianne Lurie
Judi Sedivy
Xin Wang
Dan M. Granoff
Lucy McNamara
spellingShingle Deirdre Nolfi-Donegan
Monica Konar
Vianca Vianzon
Jessica MacNeil
James Cooper
Perrianne Lurie
Judi Sedivy
Xin Wang
Dan M. Granoff
Lucy McNamara
Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab
Emerging Infectious Diseases
paroxysmal nocturnal hemoglobinuria
MenB-4C
4CMenB
Bexsero
Soliris
eculizumab
author_facet Deirdre Nolfi-Donegan
Monica Konar
Vianca Vianzon
Jessica MacNeil
James Cooper
Perrianne Lurie
Judi Sedivy
Xin Wang
Dan M. Granoff
Lucy McNamara
author_sort Deirdre Nolfi-Donegan
title Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab
title_short Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab
title_full Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab
title_fullStr Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab
title_full_unstemmed Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab
title_sort fatal nongroupable neisseria meningitidis disease in vaccinated patient receiving eculizumab
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2018-08-01
description Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.
topic paroxysmal nocturnal hemoglobinuria
MenB-4C
4CMenB
Bexsero
Soliris
eculizumab
url https://wwwnc.cdc.gov/eid/article/24/8/18-0228_article
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AT monicakonar fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
AT viancavianzon fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
AT jessicamacneil fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
AT jamescooper fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
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AT xinwang fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
AT danmgranoff fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
AT lucymcnamara fatalnongroupableneisseriameningitidisdiseaseinvaccinatedpatientreceivingeculizumab
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