Inhibition of Ubiquitin Specific Protease 1 Sensitizes Colorectal Cancer Cells to DNA-Damaging Chemotherapeutics

Inhibition of Ubiquitin Specific Protease 1 Sensitizes Colorectal Cancer Cells to DNA-Damaging Chemotherapeutics

Mutations and altered expression of deubiquitinating enzymes (DUBs) have been found associated with many human diseases including cancers. In this study, Ubiquitin specific protease 1 (USP1) expression was found significantly increased in some colorectal cancers (CRC). The elevated USP1 level was as...

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Bibliographic Details
Main Authors: Xin Xu, Shaoyan Li, Ximao Cui, Kunkun Han, Jun Wang, Xiaodan Hou, Long Cui, Songbing He, Jiecheng Xiao, Yili Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
deubiquitinating enzymes
ubiquitin specific protease 1
USP1
colorectal cancer
chemotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01406/full

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