FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective c...

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Bibliographic Details
Main Authors: Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Molecular Oncology
Subjects:
CIE
CME
endocytosis
FGFR
protein transport
signaling
Online Access:https://doi.org/10.1002/1878-0261.12740

Internet

https://doi.org/10.1002/1878-0261.12740

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