Multifocal motor neuropathy and visual pathway impairment: A case report
Background: Multifocal motor neuropathy (MMN) occasionally presents with cranial nerve involvement. However, no MMN cases with visual pathway impairment demonstrated by visual evoked potential (VEP) have been reported. Case report: A 36-year-old man was admitted to our hospital with progressive musc...
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doaj-41b6a98b07c54f2fbd8677c59ca7140a2021-07-03T04:48:18ZengElsevierClinical Neurophysiology Practice2467-981X2021-01-016191193Multifocal motor neuropathy and visual pathway impairment: A case reportKeisuke Kido0Shinichi Wada1Yuwa Oka2Yuta Terada3Manabu Inoue4Toshiaki Hamano5Center for Sleep-related Disorders, Kansai Electric Power Hospital, Osaka, Japan; Division of Sleep Medicine, Kansai Electric Power Medical Research Institute, Osaka, Japan; Corresponding author at: Division of Sleep Medicine, Kansai Electric Power Medical Research Institute, 2-1-7 Fukushima, Fukushima, Osaka 555-0003, Japan.Department of Neurology, Kansai Electric Power Hospital, Osaka, JapanDivision of Clinical Neurology, Kansai Electric Power Medical Research Institute, Osaka, Japan; Department of Neurology, Kitano Hospital, Osaka, JapanDepartment of Neurology, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Neurology, Osaka City General Hospital, Osaka, JapanDepartment of Neurology, Kansai Electric Power Hospital, Osaka, Japan; Division of Clinical Neurology, Kansai Electric Power Medical Research Institute, Osaka, JapanBackground: Multifocal motor neuropathy (MMN) occasionally presents with cranial nerve involvement. However, no MMN cases with visual pathway impairment demonstrated by visual evoked potential (VEP) have been reported. Case report: A 36-year-old man was admitted to our hospital with progressive muscular weakness. On admission, neurological findings revealed bilateral muscle weakness and atrophy of the distal upper limbs. The blood tests were positive for GM-1 ganglioside antibodies. Nerve conduction studies revealed bilateral conduction block in the median nerve. He was diagnosed with MMN. Intravenous immunoglobulin treatment improved muscle weakness and blurred vision, which was not a complaint when he was first seen. Moreover, VEP showed a post-treatment shortening of P100 latency. These treatment effects were consistently observed for 3.5 years. Significance: Our findings suggested that MMN could affect the visual pathway through autoimmune mechanisms.http://www.sciencedirect.com/science/article/pii/S2467981X21000299Nerve conduction studyVisual evoked potentialIntravenous immunoglobulin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keisuke Kido Shinichi Wada Yuwa Oka Yuta Terada Manabu Inoue Toshiaki Hamano |
spellingShingle |
Keisuke Kido Shinichi Wada Yuwa Oka Yuta Terada Manabu Inoue Toshiaki Hamano Multifocal motor neuropathy and visual pathway impairment: A case report Clinical Neurophysiology Practice Nerve conduction study Visual evoked potential Intravenous immunoglobulin |
author_facet |
Keisuke Kido Shinichi Wada Yuwa Oka Yuta Terada Manabu Inoue Toshiaki Hamano |
author_sort |
Keisuke Kido |
title |
Multifocal motor neuropathy and visual pathway impairment: A case report |
title_short |
Multifocal motor neuropathy and visual pathway impairment: A case report |
title_full |
Multifocal motor neuropathy and visual pathway impairment: A case report |
title_fullStr |
Multifocal motor neuropathy and visual pathway impairment: A case report |
title_full_unstemmed |
Multifocal motor neuropathy and visual pathway impairment: A case report |
title_sort |
multifocal motor neuropathy and visual pathway impairment: a case report |
publisher |
Elsevier |
series |
Clinical Neurophysiology Practice |
issn |
2467-981X |
publishDate |
2021-01-01 |
description |
Background: Multifocal motor neuropathy (MMN) occasionally presents with cranial nerve involvement. However, no MMN cases with visual pathway impairment demonstrated by visual evoked potential (VEP) have been reported. Case report: A 36-year-old man was admitted to our hospital with progressive muscular weakness. On admission, neurological findings revealed bilateral muscle weakness and atrophy of the distal upper limbs. The blood tests were positive for GM-1 ganglioside antibodies. Nerve conduction studies revealed bilateral conduction block in the median nerve. He was diagnosed with MMN. Intravenous immunoglobulin treatment improved muscle weakness and blurred vision, which was not a complaint when he was first seen. Moreover, VEP showed a post-treatment shortening of P100 latency. These treatment effects were consistently observed for 3.5 years. Significance: Our findings suggested that MMN could affect the visual pathway through autoimmune mechanisms. |
topic |
Nerve conduction study Visual evoked potential Intravenous immunoglobulin |
url |
http://www.sciencedirect.com/science/article/pii/S2467981X21000299 |
work_keys_str_mv |
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