In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA overreplication before cell division. CDC6 and CDT1...

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Bibliographic Details
Main Authors:	Sergio Muñoz, Sabela Búa, Sara Rodríguez-Acebes, Diego Megías, Sagrario Ortega, Alba de Martino, Juan Méndez
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717305260

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