Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3–5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to pro...
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BMC
2019-03-01
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Series: | Respiratory Research |
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Online Access: | http://link.springer.com/article/10.1186/s12931-019-1010-5 |
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doaj-41cd9a3e62684324bff8212baa9a43e2 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sabine Witt Ekaterina Krauss María Asunción Nieto Barbero Veronika Müller Philippe Bonniaud Carlo Vancheri Athol U. Wells Martina Vasakova Alberto Pesci Walter Klepetko Werner Seeger Bruno Crestani Reiner Leidl Rolf Holle Larissa Schwarzkopf Andreas Guenther |
spellingShingle |
Sabine Witt Ekaterina Krauss María Asunción Nieto Barbero Veronika Müller Philippe Bonniaud Carlo Vancheri Athol U. Wells Martina Vasakova Alberto Pesci Walter Klepetko Werner Seeger Bruno Crestani Reiner Leidl Rolf Holle Larissa Schwarzkopf Andreas Guenther Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis Respiratory Research Idiopathic pulmonary fibrosis Rare diseases Quality of life Patient-reported outcome |
author_facet |
Sabine Witt Ekaterina Krauss María Asunción Nieto Barbero Veronika Müller Philippe Bonniaud Carlo Vancheri Athol U. Wells Martina Vasakova Alberto Pesci Walter Klepetko Werner Seeger Bruno Crestani Reiner Leidl Rolf Holle Larissa Schwarzkopf Andreas Guenther |
author_sort |
Sabine Witt |
title |
Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis |
title_short |
Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis |
title_full |
Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis |
title_fullStr |
Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis |
title_full_unstemmed |
Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis |
title_sort |
psychometric properties and minimal important differences of sf-36 in idiopathic pulmonary fibrosis |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2019-03-01 |
description |
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3–5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimally important differences (MID). Methods Data source was the European IPF Registry (eurIPFreg). The psychometric properties of the SF-36 version 2 were evaluated based on objective clinical measures as well as subjective perception. We analysed acceptance, feasibility, discrimination ability, construct and criterion validity, responsiveness and test-retest-reliability. MIDs were estimated via distribution and anchor-based approaches. Results The study population included 258 individuals (73.3% male; mean age 67.3 years, SD 10.7). Of them 75.2% (194 individuals) had no missing item. The distribution of several items was skewed, although floor effect was acceptable. Physical component score (PCS) correlated significantly and moderately with several anchors, whereas the correlations of mental component score (MCS) and anchors were only small. The tests showed mainly significant lower HRQL in individuals with long-term oxygen therapy. Analyses in stable individuals did not show significant changes of HRQL except for one dimension and anchor. Individuals with relevant changes of the health status based on the anchors had significant changes in all SF-36 dimensions and summary scales except for the dimension PAIN. PCS and MCS had mean MIDs of five and six, respectively. Mean MIDs of the dimensions ranged from seven to 21. Conclusion It seems that the SF-36 is a valid instrument to measure HRQL in IPF and so can be used in RCTs or individual monitoring of disease. Nevertheless, the additional evaluation of longitudinal aspects and MIDs can be recommended to further analyse these factors. Our findings have a great potential impact on the evaluation of IPF patients. Trial registration The eurIPFreg and eurIPFbank are listed in https://clinicaltrials.gov (NCT02951416). |
topic |
Idiopathic pulmonary fibrosis Rare diseases Quality of life Patient-reported outcome |
url |
http://link.springer.com/article/10.1186/s12931-019-1010-5 |
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doaj-41cd9a3e62684324bff8212baa9a43e22020-11-25T03:35:36ZengBMCRespiratory Research1465-993X2019-03-0120111110.1186/s12931-019-1010-5Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary FibrosisSabine Witt0Ekaterina Krauss1María Asunción Nieto Barbero2Veronika Müller3Philippe Bonniaud4Carlo Vancheri5Athol U. Wells6Martina Vasakova7Alberto Pesci8Walter Klepetko9Werner Seeger10Bruno Crestani11Reiner Leidl12Rolf Holle13Larissa Schwarzkopf14Andreas Guenther15Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)European IPF Registry & Biobank (eurIPFreg/bank)Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M)Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M)Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Health Economics and Health Care Management, Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M)European IPF Registry & Biobank (eurIPFreg/bank)Abstract Background Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3–5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimally important differences (MID). Methods Data source was the European IPF Registry (eurIPFreg). The psychometric properties of the SF-36 version 2 were evaluated based on objective clinical measures as well as subjective perception. We analysed acceptance, feasibility, discrimination ability, construct and criterion validity, responsiveness and test-retest-reliability. MIDs were estimated via distribution and anchor-based approaches. Results The study population included 258 individuals (73.3% male; mean age 67.3 years, SD 10.7). Of them 75.2% (194 individuals) had no missing item. The distribution of several items was skewed, although floor effect was acceptable. Physical component score (PCS) correlated significantly and moderately with several anchors, whereas the correlations of mental component score (MCS) and anchors were only small. The tests showed mainly significant lower HRQL in individuals with long-term oxygen therapy. Analyses in stable individuals did not show significant changes of HRQL except for one dimension and anchor. Individuals with relevant changes of the health status based on the anchors had significant changes in all SF-36 dimensions and summary scales except for the dimension PAIN. PCS and MCS had mean MIDs of five and six, respectively. Mean MIDs of the dimensions ranged from seven to 21. Conclusion It seems that the SF-36 is a valid instrument to measure HRQL in IPF and so can be used in RCTs or individual monitoring of disease. Nevertheless, the additional evaluation of longitudinal aspects and MIDs can be recommended to further analyse these factors. Our findings have a great potential impact on the evaluation of IPF patients. Trial registration The eurIPFreg and eurIPFbank are listed in https://clinicaltrials.gov (NCT02951416).http://link.springer.com/article/10.1186/s12931-019-1010-5Idiopathic pulmonary fibrosisRare diseasesQuality of lifePatient-reported outcome |