Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease
Insects represent the largest and most diverse group of organisms on earth and are potential food and drug resources. Recently, we have demonstrated that a Forsythia viridissima extract prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAF...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-06-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6643/10/6/735 |
id |
doaj-41cea920a7ba4b758566dfe3a3f24138 |
---|---|
record_format |
Article |
spelling |
doaj-41cea920a7ba4b758566dfe3a3f241382020-11-25T00:40:40ZengMDPI AGNutrients2072-66432018-06-0110673510.3390/nu10060735nu10060735Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver DiseaseA-Rang Im0Won-Kyung Yang1Yang-Chun Park2Seung Hyung Kim3Sungwook Chae4Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34053, KoreaInstitute of Traditional Medicine and Bioscience, 62 Daehak-ro, Dong-gu, Daejeon University, Daejeon 34520, KoreaDivision of Respiratory Systems, Department of Internal Medicine, College of Korean Medicine, Daejeon University, 176 Daeduk-ro, Seo-gu, Daejeon 35235, KoreaInstitute of Traditional Medicine and Bioscience, 62 Daehak-ro, Dong-gu, Daejeon University, Daejeon 34520, KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34053, KoreaInsects represent the largest and most diverse group of organisms on earth and are potential food and drug resources. Recently, we have demonstrated that a Forsythia viridissima extract prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we aimed to evaluate the hepatoprotective effects of extracts of the insects Protaetia brevitarsis seulensis Kolbe, 1886 (PB), Oxya chinensis sinuosa Mishchenko, 1951 (OC), and Gryllus bimaculatus De Geer, 1773 (GB) in a high-fat diet (HFD)-induced NAFLD animal model, as well as to elucidate the underlying mechanisms. The effects of the supplementation with PB, OC, and GB extracts were evaluated histopathologically and histochemically. PB, OC, and GB extract supplementation inhibited the HFD-induced increase in body weight and body fat mass and ameliorated other adverse changes, resulting in decreased liver function parameters, lower serum triglyceride and cholesterol levels, and increased serum adiponectin levels. The expression of hepatic genes involved in lipid droplet accumulation and in fatty acid uptake also decreased upon treatment of HFD-fed mice with the extracts. These results provide evidence of the protective effects of the PB, OC, and GB extracts against HFD-induced fatty liver disease in an animal model.http://www.mdpi.com/2072-6643/10/6/735nonalcoholic fatty liver diseaseedible insectProtaetia brevitarsis seulensisOxya chinensis sinuosaGryllus bimaculatushepatoprotection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A-Rang Im Won-Kyung Yang Yang-Chun Park Seung Hyung Kim Sungwook Chae |
spellingShingle |
A-Rang Im Won-Kyung Yang Yang-Chun Park Seung Hyung Kim Sungwook Chae Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease Nutrients nonalcoholic fatty liver disease edible insect Protaetia brevitarsis seulensis Oxya chinensis sinuosa Gryllus bimaculatus hepatoprotection |
author_facet |
A-Rang Im Won-Kyung Yang Yang-Chun Park Seung Hyung Kim Sungwook Chae |
author_sort |
A-Rang Im |
title |
Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease |
title_short |
Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease |
title_full |
Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease |
title_fullStr |
Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease |
title_full_unstemmed |
Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease |
title_sort |
hepatoprotective effects of insect extracts in an animal model of nonalcoholic fatty liver disease |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-06-01 |
description |
Insects represent the largest and most diverse group of organisms on earth and are potential food and drug resources. Recently, we have demonstrated that a Forsythia viridissima extract prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we aimed to evaluate the hepatoprotective effects of extracts of the insects Protaetia brevitarsis seulensis Kolbe, 1886 (PB), Oxya chinensis sinuosa Mishchenko, 1951 (OC), and Gryllus bimaculatus De Geer, 1773 (GB) in a high-fat diet (HFD)-induced NAFLD animal model, as well as to elucidate the underlying mechanisms. The effects of the supplementation with PB, OC, and GB extracts were evaluated histopathologically and histochemically. PB, OC, and GB extract supplementation inhibited the HFD-induced increase in body weight and body fat mass and ameliorated other adverse changes, resulting in decreased liver function parameters, lower serum triglyceride and cholesterol levels, and increased serum adiponectin levels. The expression of hepatic genes involved in lipid droplet accumulation and in fatty acid uptake also decreased upon treatment of HFD-fed mice with the extracts. These results provide evidence of the protective effects of the PB, OC, and GB extracts against HFD-induced fatty liver disease in an animal model. |
topic |
nonalcoholic fatty liver disease edible insect Protaetia brevitarsis seulensis Oxya chinensis sinuosa Gryllus bimaculatus hepatoprotection |
url |
http://www.mdpi.com/2072-6643/10/6/735 |
work_keys_str_mv |
AT arangim hepatoprotectiveeffectsofinsectextractsinananimalmodelofnonalcoholicfattyliverdisease AT wonkyungyang hepatoprotectiveeffectsofinsectextractsinananimalmodelofnonalcoholicfattyliverdisease AT yangchunpark hepatoprotectiveeffectsofinsectextractsinananimalmodelofnonalcoholicfattyliverdisease AT seunghyungkim hepatoprotectiveeffectsofinsectextractsinananimalmodelofnonalcoholicfattyliverdisease AT sungwookchae hepatoprotectiveeffectsofinsectextractsinananimalmodelofnonalcoholicfattyliverdisease |
_version_ |
1725288834551250944 |