Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride produced by fermentation with the genetically modified strain of Corynebacterium glutamicu...
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doaj-41d3a4ca38254a53a824fb58340ac7b92021-05-02T22:03:22ZengWileyEFSA Journal1831-47322020-04-01184n/an/a10.2903/j.efsa.2020.6078Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria deLourdes BastosHenrik ChristensenBirgit DusemundMojca Kos DurjavaMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosYolanda SanzRoberto Edoardo VillaRuud WoutersenPier Sandro CocconcelliBoet GlandorfLieve HermanMiguel Prieto MaradonaMaria SaarelaMontserrat AnguitaJaume GalobartOrsolya HolczknechtPaola ManiniElisa PettenatiFabiola PizzoJordi Tarrés‐CallAbstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride produced by fermentation with the genetically modified strain of Corynebacterium glutamicum DSM 32932. Neither the production strain nor its recombinant DNA were detected in the final product. The additive does not pose any safety concern associated with the genetic modification of the production strain. l‐Lysine HCl produced by C. glutamicum DSM 32932 is considered safe for the target species, for the consumer and for the environment. l‐Lysine HCl produced by C. glutamicum DSM 32932 is not toxic by inhalation; it is not irritant to skin and not a skin sensitiser. The additive is not corrosive to eyes but it should be considered as an eye irritant. In general, l‐lysine HCl is considered as an efficacious source of the essential amino acid l‐lysine for non‐ruminant animal species. For the supplemental l‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.https://doi.org/10.2903/j.efsa.2020.6078nutritional additiveamino acidlysine monohydrochloridesafetyefficacy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria deLourdes Bastos Henrik Christensen Birgit Dusemund Mojca Kos Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Pier Sandro Cocconcelli Boet Glandorf Lieve Herman Miguel Prieto Maradona Maria Saarela Montserrat Anguita Jaume Galobart Orsolya Holczknecht Paola Manini Elisa Pettenati Fabiola Pizzo Jordi Tarrés‐Call |
spellingShingle |
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria deLourdes Bastos Henrik Christensen Birgit Dusemund Mojca Kos Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Pier Sandro Cocconcelli Boet Glandorf Lieve Herman Miguel Prieto Maradona Maria Saarela Montserrat Anguita Jaume Galobart Orsolya Holczknecht Paola Manini Elisa Pettenati Fabiola Pizzo Jordi Tarrés‐Call Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species EFSA Journal nutritional additive amino acid lysine monohydrochloride safety efficacy |
author_facet |
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria deLourdes Bastos Henrik Christensen Birgit Dusemund Mojca Kos Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Pier Sandro Cocconcelli Boet Glandorf Lieve Herman Miguel Prieto Maradona Maria Saarela Montserrat Anguita Jaume Galobart Orsolya Holczknecht Paola Manini Elisa Pettenati Fabiola Pizzo Jordi Tarrés‐Call |
author_sort |
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
title |
Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species |
title_short |
Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species |
title_full |
Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species |
title_fullStr |
Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species |
title_full_unstemmed |
Safety and efficacy of l‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species |
title_sort |
safety and efficacy of l‐lysine monohydrochloride produced by fermentation with corynebacterium glutamicum dsm 32932 for all animal species |
publisher |
Wiley |
series |
EFSA Journal |
issn |
1831-4732 |
publishDate |
2020-04-01 |
description |
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride produced by fermentation with the genetically modified strain of Corynebacterium glutamicum DSM 32932. Neither the production strain nor its recombinant DNA were detected in the final product. The additive does not pose any safety concern associated with the genetic modification of the production strain. l‐Lysine HCl produced by C. glutamicum DSM 32932 is considered safe for the target species, for the consumer and for the environment. l‐Lysine HCl produced by C. glutamicum DSM 32932 is not toxic by inhalation; it is not irritant to skin and not a skin sensitiser. The additive is not corrosive to eyes but it should be considered as an eye irritant. In general, l‐lysine HCl is considered as an efficacious source of the essential amino acid l‐lysine for non‐ruminant animal species. For the supplemental l‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen. |
topic |
nutritional additive amino acid lysine monohydrochloride safety efficacy |
url |
https://doi.org/10.2903/j.efsa.2020.6078 |
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