Disposition kinetic and bioavailability of florfenicol in buffalo calves
The Pharmacokinetics of florfenicol was studied in buffalo calves following single intravenous and intramuscular administration of 20 mg kg-1 b.wt. Florfenicol concentration in both serum and urine were determined by microbiological assay using Bacillus subtilis (ATCC 6633) as test organism. After i...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Beni-Suef University
2005-12-01
|
Series: | Journal of Veterinary Medical Research |
Subjects: | |
Online Access: | https://jvmr.journals.ekb.eg/article_77933.html |
id |
doaj-41d605f5ac0f498daf5a893f759691cd |
---|---|
record_format |
Article |
spelling |
doaj-41d605f5ac0f498daf5a893f759691cd2020-11-25T02:23:36ZengBeni-Suef University Journal of Veterinary Medical Research 2357-05122357-05202005-12-011526469 Disposition kinetic and bioavailability of florfenicol in buffalo calvesA. A. M. El- Gendy0 M. A. Tohamy1M. Ismail2Pharmacology Department, Faculty of Veterinary Medicine Beni-suef University, Beni-suef, EgyptPharmacology Department, Faculty of Veterinary Medicine Beni-suef University, Beni-suef, EgyptPharmacology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptThe Pharmacokinetics of florfenicol was studied in buffalo calves following single intravenous and intramuscular administration of 20 mg kg-1 b.wt. Florfenicol concentration in both serum and urine were determined by microbiological assay using Bacillus subtilis (ATCC 6633) as test organism. After intravenous injection the serum florfenicol concentration time course obeys two-compartment open model with distribution (t0.5 ()) and elimination (t0.5 ()) half lives of 0.381 ± 0.004 and 2.89 + 0.263 h., respectively. Total body clearance (CLB) and steady state volume of distribution (Vdss) were 3.6 ± 0.30 ml kg-1 min-1 and 1.70 ± 0.010 l kg-1., respectively. After intramuscular administration the observed mean peak serum concentration (Cmax) was 2.32 ± 0.052 3g ml-1 achieved after maximum time (Tmax) of one hour postinjection. The systemic bioavailability after intramuscular administration was 27.43 % and the plasma protein binding was 13.5 %. https://jvmr.journals.ekb.eg/article_77933.htmldisposition; kinetic; bioavailability; florfenicol; buffalo calves |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. A. M. El- Gendy M. A. Tohamy M. Ismail |
spellingShingle |
A. A. M. El- Gendy M. A. Tohamy M. Ismail Disposition kinetic and bioavailability of florfenicol in buffalo calves Journal of Veterinary Medical Research disposition; kinetic; bioavailability; florfenicol; buffalo calves |
author_facet |
A. A. M. El- Gendy M. A. Tohamy M. Ismail |
author_sort |
A. A. M. El- Gendy |
title |
Disposition kinetic and bioavailability of florfenicol in buffalo calves |
title_short |
Disposition kinetic and bioavailability of florfenicol in buffalo calves |
title_full |
Disposition kinetic and bioavailability of florfenicol in buffalo calves |
title_fullStr |
Disposition kinetic and bioavailability of florfenicol in buffalo calves |
title_full_unstemmed |
Disposition kinetic and bioavailability of florfenicol in buffalo calves |
title_sort |
disposition kinetic and bioavailability of florfenicol in buffalo calves |
publisher |
Beni-Suef University |
series |
Journal of Veterinary Medical Research |
issn |
2357-0512 2357-0520 |
publishDate |
2005-12-01 |
description |
The Pharmacokinetics of florfenicol was studied in buffalo calves following single intravenous and intramuscular administration of 20 mg kg-1 b.wt. Florfenicol concentration in both serum and urine were determined by microbiological assay using Bacillus subtilis (ATCC 6633) as test organism. After intravenous injection the serum florfenicol concentration time course obeys two-compartment open model with distribution (t0.5 ()) and elimination (t0.5 ()) half lives of 0.381 ± 0.004 and 2.89 + 0.263 h., respectively. Total body clearance (CLB) and steady state volume of distribution (Vdss) were 3.6 ± 0.30 ml kg-1 min-1 and 1.70 ± 0.010 l kg-1., respectively. After intramuscular administration the observed mean peak serum concentration (Cmax) was 2.32 ± 0.052 3g ml-1 achieved after maximum time (Tmax) of one hour postinjection. The systemic bioavailability after intramuscular administration was 27.43 % and the plasma protein binding was 13.5 %. |
topic |
disposition; kinetic; bioavailability; florfenicol; buffalo calves |
url |
https://jvmr.journals.ekb.eg/article_77933.html |
work_keys_str_mv |
AT aamelgendy dispositionkineticandbioavailabilityofflorfenicolinbuffalocalves AT matohamy dispositionkineticandbioavailabilityofflorfenicolinbuffalocalves AT mismail dispositionkineticandbioavailabilityofflorfenicolinbuffalocalves |
_version_ |
1724858623276875776 |