A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop

Background. We report a patient who developed corneal epithelial disorder repeatedly after changing the prescription from Xalatan eye drops (Pfizer Inc.) to Latanoprost eye drops (Kaken Pharmaceutical Co., Ltd.), both containing 0.005% latanoprost. Case Report. An 88-year-old male with glaucoma had...

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Main Authors:	Yukihisa Takada, Yuka Okada, Norihito Fujita, Shizuya Saika
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Case Reports in Ophthalmological Medicine
Online Access:	http://dx.doi.org/10.1155/2012/536746

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spelling	doaj-41d8763f72d44d839ac67c04a78a2a1d2020-11-25T00:00:29ZengHindawi LimitedCase Reports in Ophthalmological Medicine2090-67222090-67302012-01-01201210.1155/2012/536746536746A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye DropYukihisa Takada0Yuka Okada1Norihito Fujita2Shizuya Saika3Department of Ophthalmology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Ophthalmology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Ophthalmology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Ophthalmology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanBackground. We report a patient who developed corneal epithelial disorder repeatedly after changing the prescription from Xalatan eye drops (Pfizer Inc.) to Latanoprost eye drops (Kaken Pharmaceutical Co., Ltd.), both containing 0.005% latanoprost. Case Report. An 88-year-old male with glaucoma had been treated with Timoptol eye drops and Xalatan eye drops for a few years. While he stayed in a health care facility for the elderly, Xalatan eye drops was changed to Latanoprost eye drops usage, and eye pain developed on the day of this change. On the next day, he visited our department, and corneal epithelial disorder was observed. The drops were discontinued, and the corneal epithelial disorder healed after 2 days. Twenty days after the first consultation, Xalatan eye drops and Latanoprost eye drops were resumed by a physician of internal medicine in the health care facility, but eye pain developed again. After discontinuation of the two drugs, Xalatan eye drops usage was resumed the next day, but no corneal epithelial disorder was observed thereafter. Conclusions. This clinical history strongly suggested the association between a generic drug, Latanoprost eye drops, and the development of corneal epithelial disorder.http://dx.doi.org/10.1155/2012/536746
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yukihisa Takada Yuka Okada Norihito Fujita Shizuya Saika
spellingShingle	Yukihisa Takada Yuka Okada Norihito Fujita Shizuya Saika A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop Case Reports in Ophthalmological Medicine
author_facet	Yukihisa Takada Yuka Okada Norihito Fujita Shizuya Saika
author_sort	Yukihisa Takada
title	A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop
title_short	A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop
title_full	A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop
title_fullStr	A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop
title_full_unstemmed	A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop
title_sort	patient with corneal epithelial disorder that developed after administration of a latanoprost generic, but not a brand-name drug, eye drop
publisher	Hindawi Limited
series	Case Reports in Ophthalmological Medicine
issn	2090-6722 2090-6730
publishDate	2012-01-01
description	Background. We report a patient who developed corneal epithelial disorder repeatedly after changing the prescription from Xalatan eye drops (Pfizer Inc.) to Latanoprost eye drops (Kaken Pharmaceutical Co., Ltd.), both containing 0.005% latanoprost. Case Report. An 88-year-old male with glaucoma had been treated with Timoptol eye drops and Xalatan eye drops for a few years. While he stayed in a health care facility for the elderly, Xalatan eye drops was changed to Latanoprost eye drops usage, and eye pain developed on the day of this change. On the next day, he visited our department, and corneal epithelial disorder was observed. The drops were discontinued, and the corneal epithelial disorder healed after 2 days. Twenty days after the first consultation, Xalatan eye drops and Latanoprost eye drops were resumed by a physician of internal medicine in the health care facility, but eye pain developed again. After discontinuation of the two drugs, Xalatan eye drops usage was resumed the next day, but no corneal epithelial disorder was observed thereafter. Conclusions. This clinical history strongly suggested the association between a generic drug, Latanoprost eye drops, and the development of corneal epithelial disorder.
url	http://dx.doi.org/10.1155/2012/536746
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A Patient with Corneal Epithelial Disorder That Developed after Administration of a Latanoprost Generic, but Not a Brand-Name Drug, Eye Drop

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