Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functi...
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20659-2 |
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doaj-41e3849697dd487fb5c3e7640b8e444b2021-01-24T12:12:36ZengNature Publishing GroupNature Communications2041-17232021-01-0112112010.1038/s41467-020-20659-2Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult miceNikos E. Papaioannou0Natallia Salei1Stephan Rambichler2Kaushikk Ravi3Jelena Popovic4Vanessa Küntzel5Christian H. K. Lehmann6Remi Fiancette7Johanna Salvermoser8Dominika W. Gajdasik9Ramona Mettler10Denise Messerer11Joana Carrelha12Caspar Ohnmacht13Dirk Haller14Ralf Stumm15Tobias Straub16Sten Eirik W. Jacobsen17Christian Schulz18David R. Withers19Gunnar Schotta20Diana Dudziak21Barbara U. Schraml22Faculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichLaboratory of Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-NürnbergInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichMedizinische Klinik und Poliklinik I, University Hospital Munich, LMU MunichHaematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of OxfordCenter of Allergy and Environment, Helmholtz Center and Technical University of MunichZIEL–Institute for Food and Health, Technische Universität MünchenInstitute of Pharmacology and Toxicology, Jena University HospitalCore Facility Bioinformatics, Biomedical Center, LMU MunichHaematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of OxfordMedizinische Klinik und Poliklinik I, University Hospital Munich, LMU MunichInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamFaculty of Medicine, Center for Integrated Protein Science Munich, LMU MunichLaboratory of Dendritic Cell Biology, Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-NürnbergFaculty of Medicine, Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU MunichType 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli.https://doi.org/10.1038/s41467-020-20659-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nikos E. Papaioannou Natallia Salei Stephan Rambichler Kaushikk Ravi Jelena Popovic Vanessa Küntzel Christian H. K. Lehmann Remi Fiancette Johanna Salvermoser Dominika W. Gajdasik Ramona Mettler Denise Messerer Joana Carrelha Caspar Ohnmacht Dirk Haller Ralf Stumm Tobias Straub Sten Eirik W. Jacobsen Christian Schulz David R. Withers Gunnar Schotta Diana Dudziak Barbara U. Schraml |
| spellingShingle |
Nikos E. Papaioannou Natallia Salei Stephan Rambichler Kaushikk Ravi Jelena Popovic Vanessa Küntzel Christian H. K. Lehmann Remi Fiancette Johanna Salvermoser Dominika W. Gajdasik Ramona Mettler Denise Messerer Joana Carrelha Caspar Ohnmacht Dirk Haller Ralf Stumm Tobias Straub Sten Eirik W. Jacobsen Christian Schulz David R. Withers Gunnar Schotta Diana Dudziak Barbara U. Schraml Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice Nature Communications |
| author_facet |
Nikos E. Papaioannou Natallia Salei Stephan Rambichler Kaushikk Ravi Jelena Popovic Vanessa Küntzel Christian H. K. Lehmann Remi Fiancette Johanna Salvermoser Dominika W. Gajdasik Ramona Mettler Denise Messerer Joana Carrelha Caspar Ohnmacht Dirk Haller Ralf Stumm Tobias Straub Sten Eirik W. Jacobsen Christian Schulz David R. Withers Gunnar Schotta Diana Dudziak Barbara U. Schraml |
| author_sort |
Nikos E. Papaioannou |
| title |
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice |
| title_short |
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice |
| title_full |
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice |
| title_fullStr |
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice |
| title_full_unstemmed |
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice |
| title_sort |
environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli. |
| url |
https://doi.org/10.1038/s41467-020-20659-2 |
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