Novel pathomechanisms in inflammatory neuropathies

• Main Authors: David Schafflick, Bernd C. Kieseier, Heinz Wiendl, Gerd Meyer zu Horste
• Format: Article
• Language: English
• Published: BMC 2017-11-01
• Series: Journal of Neuroinflammation
• Subjects: Experimental autoimmune neuritis; Guillain-Barré syndrome; Chronic inflammatory demyelinating polyneuropathy; Animal model; Th17 cells
• Online Access: http://link.springer.com/article/10.1186/s12974-017-1001-8

Abstract Inflammatory neuropathies are rare autoimmune-mediated disorders affecting the peripheral nervous system. Considerable progress has recently been made in understanding pathomechanisms of these disorders which will be essential for developing novel diagnostic and therapeutic strategies in the future. Here, we summarize our current understanding of antigenic targets and the relevance of new immunological concepts for inflammatory neuropathies. In addition, we provide an overview of available animal models of acute and chronic variants and how new diagnostic tools such as magnetic resonance imaging and novel therapeutic candidates will benefit patients with inflammatory neuropathies in the future. This review thus illustrates the gap between pre-clinical and clinical findings and aims to outline future directions of development.