Overview of DNA Self-Assembling: Progresses in Biomedical Applications
Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting...
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Online Access: | https://www.mdpi.com/1999-4923/10/4/268 |
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doaj-41fa8c3606ab42409db6af859d0e2e832020-11-25T02:28:19ZengMDPI AGPharmaceutics1999-49232018-12-0110426810.3390/pharmaceutics10040268pharmaceutics10040268Overview of DNA Self-Assembling: Progresses in Biomedical ApplicationsAndreia F. Jorge0Ramon Eritja1Coimbra Chemistry Centre (CQC), Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, PortugalInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, SpainMolecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo.https://www.mdpi.com/1999-4923/10/4/268DNA self-assemblinggene deliverydrug deliveryprotein deliverytheranosticsnanomedicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreia F. Jorge Ramon Eritja |
spellingShingle |
Andreia F. Jorge Ramon Eritja Overview of DNA Self-Assembling: Progresses in Biomedical Applications Pharmaceutics DNA self-assembling gene delivery drug delivery protein delivery theranostics nanomedicine |
author_facet |
Andreia F. Jorge Ramon Eritja |
author_sort |
Andreia F. Jorge |
title |
Overview of DNA Self-Assembling: Progresses in Biomedical Applications |
title_short |
Overview of DNA Self-Assembling: Progresses in Biomedical Applications |
title_full |
Overview of DNA Self-Assembling: Progresses in Biomedical Applications |
title_fullStr |
Overview of DNA Self-Assembling: Progresses in Biomedical Applications |
title_full_unstemmed |
Overview of DNA Self-Assembling: Progresses in Biomedical Applications |
title_sort |
overview of dna self-assembling: progresses in biomedical applications |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2018-12-01 |
description |
Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo. |
topic |
DNA self-assembling gene delivery drug delivery protein delivery theranostics nanomedicine |
url |
https://www.mdpi.com/1999-4923/10/4/268 |
work_keys_str_mv |
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