Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water

Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water

A sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As...

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Main Authors: N.V. Zaitseva, O.V. Dolgilh, A.V. Krivtsov, K.G. Starkova, V.A. Luchnikova, O.A. Bubnov, E.A. Otavina, N.V. Bezruchenko, N.A. Vdovina
Format: Article
Language:English
Published: FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies” 2015-12-01
Series:Analiz Riska Zdorovʹû
Subjects:
sequencing
strontium
candidate genes
gene polymorphism
Online Access:http://journal.fcrisk.ru/eng/2015/4/3
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spelling doaj-41fb368477e049fb87d4e86ba4a18da42020-11-24T21:34:33ZengFBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”Analiz Riska Zdorovʹû2308-11552308-11632015-12-014212710.21668/health.risk/2015.4.03.engPolymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking waterN.V. Zaitseva0O.V. Dolgilh 1A.V. Krivtsov 2K.G. Starkova3V.A. Luchnikova4O.A. Bubnov5E.A. Otavina 6N.V. Bezruchenko7N.A. Vdovina8Federal Scientific Center for Medical and Preventive Health Risk Management TechnologiesFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesPerm State National Research UniversityFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesPerm State National Research UniversityFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesA sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As a result of the targeted resequencing in conditions of strontium exposure, the maximum polymorph modifications of the following genes are defined: sulfotransferase 1A1 (SULT1A1) and methylenetetrahydrofolate. It was shown that the structure of the mutations in conditions of the strontium exposure was characterized by the formation of defects in the gene mapping detoxification (38.5 % of all mutations) and immunoregulation (22.5 %). Analysis of the cause-effect relationships in the system "factor - the number of mutations" revealed that candidate genes reflecting strontium exposure conditions (content of strontium in drinking water is 1.3 MAC), are genes: cytochrome P450, glutathione - transaminase (detoxification); dopamine (CNS), interleukin 17 and the major histocompatibility complex (immune system), methylene-tetra-hydro-folate-reductase (reproduction).http://journal.fcrisk.ru/eng/2015/4/3sequencingstrontiumcandidate genesgene polymorphism
collection DOAJ
language English
format Article
sources DOAJ
author N.V. Zaitseva
O.V. Dolgilh
A.V. Krivtsov
K.G. Starkova
V.A. Luchnikova
O.A. Bubnov
E.A. Otavina
N.V. Bezruchenko
N.A. Vdovina
spellingShingle N.V. Zaitseva
O.V. Dolgilh
A.V. Krivtsov
K.G. Starkova
V.A. Luchnikova
O.A. Bubnov
E.A. Otavina
N.V. Bezruchenko
N.A. Vdovina
Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
Analiz Riska Zdorovʹû
sequencing
strontium
candidate genes
gene polymorphism
author_facet N.V. Zaitseva
O.V. Dolgilh
A.V. Krivtsov
K.G. Starkova
V.A. Luchnikova
O.A. Bubnov
E.A. Otavina
N.V. Bezruchenko
N.A. Vdovina
author_sort N.V. Zaitseva
title Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
title_short Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
title_full Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
title_fullStr Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
title_full_unstemmed Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
title_sort polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water
publisher FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
series Analiz Riska Zdorovʹû
issn 2308-1155
2308-1163
publishDate 2015-12-01
description A sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As a result of the targeted resequencing in conditions of strontium exposure, the maximum polymorph modifications of the following genes are defined: sulfotransferase 1A1 (SULT1A1) and methylenetetrahydrofolate. It was shown that the structure of the mutations in conditions of the strontium exposure was characterized by the formation of defects in the gene mapping detoxification (38.5 % of all mutations) and immunoregulation (22.5 %). Analysis of the cause-effect relationships in the system "factor - the number of mutations" revealed that candidate genes reflecting strontium exposure conditions (content of strontium in drinking water is 1.3 MAC), are genes: cytochrome P450, glutathione - transaminase (detoxification); dopamine (CNS), interleukin 17 and the major histocompatibility complex (immune system), methylene-tetra-hydro-folate-reductase (reproduction).
topic sequencing
strontium
candidate genes
gene polymorphism
url http://journal.fcrisk.ru/eng/2015/4/3
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