SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis.
OBJECTIVE:To investigate whether signal to noise (SNR) analysis of contrast-enhanced MRI gives additional benefit for early disease detection by Magnetic Resonance Imaging (MRI) of experimental rheumatoid arthritis (RA) in a small animal model. METHODS:We applied contrast-enhanced MRI at 7T in DBA m...
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Online Access: | https://doi.org/10.1371/journal.pone.0213082 |
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doaj-41fb62d62176481b85ffb3194777972c2021-03-03T20:50:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01143e021308210.1371/journal.pone.0213082SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis.Florian T GassertFelix G GassertGeoffrey J ToppingErnst J RummenyMoritz WildgruberReinhard MeierMelanie A KimmOBJECTIVE:To investigate whether signal to noise (SNR) analysis of contrast-enhanced MRI gives additional benefit for early disease detection by Magnetic Resonance Imaging (MRI) of experimental rheumatoid arthritis (RA) in a small animal model. METHODS:We applied contrast-enhanced MRI at 7T in DBA mice with or without collagen-induced arthritis (CIA). Clinical score, OMERACT RAMRIS analysis and analysis of signal to noise ratios (SNR) of regions of interest in RA bearing mice, methotrexate/methylprednisolone acetate treated RA and control animals were compared with respect to benefit for early diagnosis. RESULTS:While treated RA and control animals did not show signs of RA activity in any of the above-mentioned scoring methods at any time point analyzed, RA animals revealed characteristic signs of RA in RAMRIS at the same time point when RA was detected clinically through scoring of the paws. The MR-based SNR analysis detected signs of synovitis, the earliest indication of RA, not only in late clinical stages, but also at an early stage when little or no clinical signs of RA were present in CIA animals and RAMRIS did not allow a distinct early detection. CONCLUSION:SNR analysis of contrast-enhanced MR imaging provides additional benefit for early arthritis detection in CIA mice.https://doi.org/10.1371/journal.pone.0213082 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Florian T Gassert Felix G Gassert Geoffrey J Topping Ernst J Rummeny Moritz Wildgruber Reinhard Meier Melanie A Kimm |
spellingShingle |
Florian T Gassert Felix G Gassert Geoffrey J Topping Ernst J Rummeny Moritz Wildgruber Reinhard Meier Melanie A Kimm SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. PLoS ONE |
author_facet |
Florian T Gassert Felix G Gassert Geoffrey J Topping Ernst J Rummeny Moritz Wildgruber Reinhard Meier Melanie A Kimm |
author_sort |
Florian T Gassert |
title |
SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. |
title_short |
SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. |
title_full |
SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. |
title_fullStr |
SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. |
title_full_unstemmed |
SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis. |
title_sort |
snr analysis of contrast-enhanced mr imaging for early detection of rheumatoid arthritis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
OBJECTIVE:To investigate whether signal to noise (SNR) analysis of contrast-enhanced MRI gives additional benefit for early disease detection by Magnetic Resonance Imaging (MRI) of experimental rheumatoid arthritis (RA) in a small animal model. METHODS:We applied contrast-enhanced MRI at 7T in DBA mice with or without collagen-induced arthritis (CIA). Clinical score, OMERACT RAMRIS analysis and analysis of signal to noise ratios (SNR) of regions of interest in RA bearing mice, methotrexate/methylprednisolone acetate treated RA and control animals were compared with respect to benefit for early diagnosis. RESULTS:While treated RA and control animals did not show signs of RA activity in any of the above-mentioned scoring methods at any time point analyzed, RA animals revealed characteristic signs of RA in RAMRIS at the same time point when RA was detected clinically through scoring of the paws. The MR-based SNR analysis detected signs of synovitis, the earliest indication of RA, not only in late clinical stages, but also at an early stage when little or no clinical signs of RA were present in CIA animals and RAMRIS did not allow a distinct early detection. CONCLUSION:SNR analysis of contrast-enhanced MR imaging provides additional benefit for early arthritis detection in CIA mice. |
url |
https://doi.org/10.1371/journal.pone.0213082 |
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