Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.
Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors. The high expression of HMG1 could alter DNA structure resulting in GCRs. S...
Main Authors: | Nilabja Sikdar, Soma Banerjee, Han Zhang, Stephanie Smith, Kyungjae Myung |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-12-01
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Series: | PLoS Genetics |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19057669/?tool=EBI |
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