Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions
Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between the HLA-B∗58 : 01 allele and allopurinol-induced SCARs is well recognized. Screening for HLA-B∗58 : 01 allele before prescribing allopurinol in some populations has been recommended. Severa...
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doaj-4211ebf212714520b2e723735db8d4c62020-11-24T21:09:45ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/27387842738784Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse ReactionsNiwat Saksit0Nontaya Nakkam1Parinya Konyoung2Usanee Khunarkornsiri3Wongwiwat Tassaneeyakul4Pansu Chumworathayi5Sirimas Kanjanawart6Chonlaphat Sukasem7Alisara Sangviroon8Oranuch Pattanacheewapull9Wichittra Tassaneeyakul10Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandPharmacy Unit, Udon Thani Hospital, Udon Thani, ThailandPharmacy Unit, Udon Thani Hospital, Udon Thani, ThailandFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, ThailandPharmacy Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandDepartment of Pathology, Division of Pharmacogenomics and Personalized Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandPharmacy Unit, Police General Hospital, Bangkok, ThailandPharmacy Department, Khon Kaen Hospital, Khon Kaen, ThailandDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandSevere cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between the HLA-B∗58 : 01 allele and allopurinol-induced SCARs is well recognized. Screening for HLA-B∗58 : 01 allele before prescribing allopurinol in some populations has been recommended. Several single-nucleotide polymorphisms (SNPs) in chromosome 6 have been found to be tightly linked with the HLA allele, and these SNPs have been proposed as surrogate markers of the HLA-B∗58 : 01 allele. This study aimed to evaluate the association between three SNPs in chromosome 6 and allopurinol-induced SCARs in a Thai population. The linkage disequilibrium between the HLA-B∗58 : 01 allele and these SNPs was also evaluated. Results showed that three SNPs including rs9263726, rs2734583, and rs3099844 were significantly associated with allopurinol-induced SCARs but with a lower degree of association when compared with the HLA-B∗58 : 01 allele. The sensitivity, specificity, PPV, and NPV of these SNPs were comparable to those of the HLA-B∗58 : 01 allele. Although detection of the SNP is simpler and less expensive compared with that of the HLA-B∗58 : 01 allele, these SNPs were not perfectly linked with the HLA-B∗58 : 01 allele. Screening using these SNPs as surrogate markers of the HLA-B∗58 : 01 allele to avoid SCARs prior to allopurinol administration needs caution because of their imperfect linkage with the HLA-B∗58 : 01 allele.http://dx.doi.org/10.1155/2017/2738784 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Niwat Saksit Nontaya Nakkam Parinya Konyoung Usanee Khunarkornsiri Wongwiwat Tassaneeyakul Pansu Chumworathayi Sirimas Kanjanawart Chonlaphat Sukasem Alisara Sangviroon Oranuch Pattanacheewapull Wichittra Tassaneeyakul |
spellingShingle |
Niwat Saksit Nontaya Nakkam Parinya Konyoung Usanee Khunarkornsiri Wongwiwat Tassaneeyakul Pansu Chumworathayi Sirimas Kanjanawart Chonlaphat Sukasem Alisara Sangviroon Oranuch Pattanacheewapull Wichittra Tassaneeyakul Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions Journal of Immunology Research |
author_facet |
Niwat Saksit Nontaya Nakkam Parinya Konyoung Usanee Khunarkornsiri Wongwiwat Tassaneeyakul Pansu Chumworathayi Sirimas Kanjanawart Chonlaphat Sukasem Alisara Sangviroon Oranuch Pattanacheewapull Wichittra Tassaneeyakul |
author_sort |
Niwat Saksit |
title |
Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions |
title_short |
Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions |
title_full |
Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions |
title_fullStr |
Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions |
title_full_unstemmed |
Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions |
title_sort |
comparison between the hla-b∗58 : 01 allele and single-nucleotide polymorphisms in chromosome 6 for prediction of allopurinol-induced severe cutaneous adverse reactions |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2017-01-01 |
description |
Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between the HLA-B∗58 : 01 allele and allopurinol-induced SCARs is well recognized. Screening for HLA-B∗58 : 01 allele before prescribing allopurinol in some populations has been recommended. Several single-nucleotide polymorphisms (SNPs) in chromosome 6 have been found to be tightly linked with the HLA allele, and these SNPs have been proposed as surrogate markers of the HLA-B∗58 : 01 allele. This study aimed to evaluate the association between three SNPs in chromosome 6 and allopurinol-induced SCARs in a Thai population. The linkage disequilibrium between the HLA-B∗58 : 01 allele and these SNPs was also evaluated. Results showed that three SNPs including rs9263726, rs2734583, and rs3099844 were significantly associated with allopurinol-induced SCARs but with a lower degree of association when compared with the HLA-B∗58 : 01 allele. The sensitivity, specificity, PPV, and NPV of these SNPs were comparable to those of the HLA-B∗58 : 01 allele. Although detection of the SNP is simpler and less expensive compared with that of the HLA-B∗58 : 01 allele, these SNPs were not perfectly linked with the HLA-B∗58 : 01 allele. Screening using these SNPs as surrogate markers of the HLA-B∗58 : 01 allele to avoid SCARs prior to allopurinol administration needs caution because of their imperfect linkage with the HLA-B∗58 : 01 allele. |
url |
http://dx.doi.org/10.1155/2017/2738784 |
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