Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the prolifer...

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Main Authors:	Tzu-Zin Huang, Bo-Wei Chen, Chiung-Yao Huang, Tsong-Long Hwang, Chokkalingam Uvarani, Chang-Feng Dai, Ping-Jyun Sung, Jui-Hsin Su, Jyh-Horng Sheu
Format:	Article
Language:	English
Published:	MDPI AG 2015-04-01
Series:	Marine Drugs
Subjects:	soft coral Cladiella hirsuta eunicellins cytotoxic activity anti-inflammatory activity
Online Access:	http://www.mdpi.com/1660-3397/13/5/2757

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spelling	doaj-4214daa469d449e7a4f6a3dcb82151782020-11-24T20:54:10ZengMDPI AGMarine Drugs1660-33972015-04-011352757276910.3390/md13052757md13052757Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsutaTzu-Zin Huang0Bo-Wei Chen1Chiung-Yao Huang2Tsong-Long Hwang3Chokkalingam Uvarani4Chang-Feng Dai5Ping-Jyun Sung6Jui-Hsin Su7Jyh-Horng Sheu8Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanGraduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanInstitute of Oceanography, National Taiwan University, Taipei 112, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanFour new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.http://www.mdpi.com/1660-3397/13/5/2757soft coralCladiella hirsutaeunicellinscytotoxic activityanti-inflammatory activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tzu-Zin Huang Bo-Wei Chen Chiung-Yao Huang Tsong-Long Hwang Chokkalingam Uvarani Chang-Feng Dai Ping-Jyun Sung Jui-Hsin Su Jyh-Horng Sheu
spellingShingle	Tzu-Zin Huang Bo-Wei Chen Chiung-Yao Huang Tsong-Long Hwang Chokkalingam Uvarani Chang-Feng Dai Ping-Jyun Sung Jui-Hsin Su Jyh-Horng Sheu Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta Marine Drugs soft coral Cladiella hirsuta eunicellins cytotoxic activity anti-inflammatory activity
author_facet	Tzu-Zin Huang Bo-Wei Chen Chiung-Yao Huang Tsong-Long Hwang Chokkalingam Uvarani Chang-Feng Dai Ping-Jyun Sung Jui-Hsin Su Jyh-Horng Sheu
author_sort	Tzu-Zin Huang
title	Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_short	Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_full	Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_fullStr	Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_full_unstemmed	Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_sort	eunicellin-based diterpenoids, hirsutalins s–v, from the formosan soft coral cladiella hirsuta
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2015-04-01
description	Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.
topic	soft coral Cladiella hirsuta eunicellins cytotoxic activity anti-inflammatory activity
url	http://www.mdpi.com/1660-3397/13/5/2757
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Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

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