Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging.
Recently published studies have elucidated alterations of mitochondrial oxidative metabolism during ageing. The intention of the present study was to evaluate the impact of ageing on cardiac high-energy phosphate metabolism and cardiac function in healthy humans. 31-phosphorus 2-dimensional chemical...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4062408?pdf=render |
id |
doaj-422316ce71724c77bfa8747654221a91 |
---|---|
record_format |
Article |
spelling |
doaj-422316ce71724c77bfa8747654221a912020-11-25T01:53:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9736810.1371/journal.pone.0097368Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging.Regina EsterhammerGert KlugChristian WolfAgnes MayrSebastian ReinstadlerHans-Josef FeistritzerBernhard MetzlerMichael F H SchockeRecently published studies have elucidated alterations of mitochondrial oxidative metabolism during ageing. The intention of the present study was to evaluate the impact of ageing on cardiac high-energy phosphate metabolism and cardiac function in healthy humans. 31-phosphorus 2-dimensional chemical shift imaging (31P 2D CSI) and echocardiography were performed in 196 healthy male volunteers divided into groups of 20 to 40 years (I, n = 43), 40 to 60 years (II, n = 123) and >60 years (III, n = 27) of age. Left ventricular PCr/β-ATP ratio, myocardial mass (MM), ejection fraction and E/A ratio were assessed. Mean PCr/β-ATP ratios were significantly different among the three groups of volunteers (I, 2.10 ± 0.37; II, 1.77 ± 0.37; III, 1.45 ± 0.28; all p<0.001). PCr/β-ATP ratios were inversely related to age (r(2) = -0.25; p<0.001) with a decrease from 2.65 by 0.02 per year of ageing. PCr/β-ATP ratios further correlated with MM (r = -0.371; p<0.001) and E/A ratios (r = 0.213; p<0.02). Moreover, E/A ratios (r = -0.502, p<0.001), MM (r = 0.304, p<0.001), glucose-levels (r = 0.157, p<0.05) and systolic blood pressure (r = 0.224, p<0.005) showed significant correlations with age. The ejection fraction did not significantly differ between the groups. This study shows that cardiac PCr/β-ATP ratios decrease moderately with age indicating an impairment of mitochondrial oxidative metabolism due to age. Furthermore, MM increases, and E/A ratio decreases with age. Both correlate with left-ventricular PCr/β-ATP ratios. The findings of the present study confirm numerous experimental studies showing an impairment of cardiac mitochondrial function with age.http://europepmc.org/articles/PMC4062408?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Regina Esterhammer Gert Klug Christian Wolf Agnes Mayr Sebastian Reinstadler Hans-Josef Feistritzer Bernhard Metzler Michael F H Schocke |
spellingShingle |
Regina Esterhammer Gert Klug Christian Wolf Agnes Mayr Sebastian Reinstadler Hans-Josef Feistritzer Bernhard Metzler Michael F H Schocke Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. PLoS ONE |
author_facet |
Regina Esterhammer Gert Klug Christian Wolf Agnes Mayr Sebastian Reinstadler Hans-Josef Feistritzer Bernhard Metzler Michael F H Schocke |
author_sort |
Regina Esterhammer |
title |
Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. |
title_short |
Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. |
title_full |
Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. |
title_fullStr |
Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. |
title_full_unstemmed |
Cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. |
title_sort |
cardiac high-energy phosphate metabolism alters with age as studied in 196 healthy males with the help of 31-phosphorus 2-dimensional chemical shift imaging. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Recently published studies have elucidated alterations of mitochondrial oxidative metabolism during ageing. The intention of the present study was to evaluate the impact of ageing on cardiac high-energy phosphate metabolism and cardiac function in healthy humans. 31-phosphorus 2-dimensional chemical shift imaging (31P 2D CSI) and echocardiography were performed in 196 healthy male volunteers divided into groups of 20 to 40 years (I, n = 43), 40 to 60 years (II, n = 123) and >60 years (III, n = 27) of age. Left ventricular PCr/β-ATP ratio, myocardial mass (MM), ejection fraction and E/A ratio were assessed. Mean PCr/β-ATP ratios were significantly different among the three groups of volunteers (I, 2.10 ± 0.37; II, 1.77 ± 0.37; III, 1.45 ± 0.28; all p<0.001). PCr/β-ATP ratios were inversely related to age (r(2) = -0.25; p<0.001) with a decrease from 2.65 by 0.02 per year of ageing. PCr/β-ATP ratios further correlated with MM (r = -0.371; p<0.001) and E/A ratios (r = 0.213; p<0.02). Moreover, E/A ratios (r = -0.502, p<0.001), MM (r = 0.304, p<0.001), glucose-levels (r = 0.157, p<0.05) and systolic blood pressure (r = 0.224, p<0.005) showed significant correlations with age. The ejection fraction did not significantly differ between the groups. This study shows that cardiac PCr/β-ATP ratios decrease moderately with age indicating an impairment of mitochondrial oxidative metabolism due to age. Furthermore, MM increases, and E/A ratio decreases with age. Both correlate with left-ventricular PCr/β-ATP ratios. The findings of the present study confirm numerous experimental studies showing an impairment of cardiac mitochondrial function with age. |
url |
http://europepmc.org/articles/PMC4062408?pdf=render |
work_keys_str_mv |
AT reginaesterhammer cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT gertklug cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT christianwolf cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT agnesmayr cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT sebastianreinstadler cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT hansjoseffeistritzer cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT bernhardmetzler cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging AT michaelfhschocke cardiachighenergyphosphatemetabolismalterswithageasstudiedin196healthymaleswiththehelpof31phosphorus2dimensionalchemicalshiftimaging |
_version_ |
1724990808082350080 |