Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia?
Background: Ventilator-associated pneumonia (VAP) is a type of lung infection that typically affects critically ill patients undergoing mechanical ventilation (MV) in the intensive care unit (ICU). Patients with type 2 diabetes mellitus (T2DM) are considered to be more susceptible to several types o...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
Series: | Journal of Research in Medical Sciences |
Subjects: | |
Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=19;epage=19;aulast=Khezri |
id |
doaj-422782a932e248a7a5e17b4dd4394876 |
---|---|
record_format |
Article |
spelling |
doaj-422782a932e248a7a5e17b4dd43948762020-11-25T01:41:23ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362016-01-01211191910.4103/1735-1995.179887Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia?Hadi Darvishi KhezriAbbas AlipourAmir Emami ZeydiAbolfazl FiruzianGhahraman MahmudiMelody Omrani NavaBackground: Ventilator-associated pneumonia (VAP) is a type of lung infection that typically affects critically ill patients undergoing mechanical ventilation (MV) in the intensive care unit (ICU). Patients with type 2 diabetes mellitus (T2DM) are considered to be more susceptible to several types of infections including community-acquired pneumonia. However, it is not clear whether T2DM is a risk factor for the development of VAP. The purpose of this study was to determine the risk of VAP for diabetic and nondiabetic mechanically ventilated trauma patients. Materials and Methods: This study is a secondary analysis of a prospective observational study of the history of T2DM in the ICU over a period of 1 year at Imam Khomeini Hospital in Iran. A total of 186 critically ill trauma patients who required at least 48 h of MV were monitored for the occurrence of VAP by their clinical pulmonary infection score (CPIS) until ICU discharge, VAP diagnosis, or death. Results: Forty-one of the 186 patients developed VAP. The median time from hospitalization to VAP was 29.09 days (95% CI: 26.27-31.9). The overall incidence of VAP was 18.82 cases per 1,000 days of intubation (95% CI: 13.86-25.57). Risk of VAP in diabetic patients was greater than nondiabetic patients after adjustments for other potential factors [hazard ratio (HR): 10.12 [95% confidence interval (CI): 5.1-20.2); P < 0.0001)]. Conclusion: The findings show that T2DM is associated with a significant increase in the occurrence of VAP in mechanically ventilated adult trauma patients.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=19;epage=19;aulast=KhezriDiabetes mellitusintensive care unit (ICU)traumaventilator-associated pneumonia (VAP) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hadi Darvishi Khezri Abbas Alipour Amir Emami Zeydi Abolfazl Firuzian Ghahraman Mahmudi Melody Omrani Nava |
spellingShingle |
Hadi Darvishi Khezri Abbas Alipour Amir Emami Zeydi Abolfazl Firuzian Ghahraman Mahmudi Melody Omrani Nava Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? Journal of Research in Medical Sciences Diabetes mellitus intensive care unit (ICU) trauma ventilator-associated pneumonia (VAP) |
author_facet |
Hadi Darvishi Khezri Abbas Alipour Amir Emami Zeydi Abolfazl Firuzian Ghahraman Mahmudi Melody Omrani Nava |
author_sort |
Hadi Darvishi Khezri |
title |
Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? |
title_short |
Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? |
title_full |
Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? |
title_fullStr |
Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? |
title_full_unstemmed |
Is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? |
title_sort |
is type 2 diabetes mellitus in mechanically ventilated adult trauma patients potentially related to the occurrence of ventilator-associated pneumonia? |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2016-01-01 |
description |
Background: Ventilator-associated pneumonia (VAP) is a type of lung infection that typically affects critically ill patients undergoing mechanical ventilation (MV) in the intensive care unit (ICU). Patients with type 2 diabetes mellitus (T2DM) are considered to be more susceptible to several types of infections including community-acquired pneumonia. However, it is not clear whether T2DM is a risk factor for the development of VAP. The purpose of this study was to determine the risk of VAP for diabetic and nondiabetic mechanically ventilated trauma patients. Materials and Methods: This study is a secondary analysis of a prospective observational study of the history of T2DM in the ICU over a period of 1 year at Imam Khomeini Hospital in Iran. A total of 186 critically ill trauma patients who required at least 48 h of MV were monitored for the occurrence of VAP by their clinical pulmonary infection score (CPIS) until ICU discharge, VAP diagnosis, or death. Results: Forty-one of the 186 patients developed VAP. The median time from hospitalization to VAP was 29.09 days (95% CI: 26.27-31.9). The overall incidence of VAP was 18.82 cases per 1,000 days of intubation (95% CI: 13.86-25.57). Risk of VAP in diabetic patients was greater than nondiabetic patients after adjustments for other potential factors [hazard ratio (HR): 10.12 [95% confidence interval (CI): 5.1-20.2); P < 0.0001)]. Conclusion: The findings show that T2DM is associated with a significant increase in the occurrence of VAP in mechanically ventilated adult trauma patients. |
topic |
Diabetes mellitus intensive care unit (ICU) trauma ventilator-associated pneumonia (VAP) |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=19;epage=19;aulast=Khezri |
work_keys_str_mv |
AT hadidarvishikhezri istype2diabetesmellitusinmechanicallyventilatedadulttraumapatientspotentiallyrelatedtotheoccurrenceofventilatorassociatedpneumonia AT abbasalipour istype2diabetesmellitusinmechanicallyventilatedadulttraumapatientspotentiallyrelatedtotheoccurrenceofventilatorassociatedpneumonia AT amiremamizeydi istype2diabetesmellitusinmechanicallyventilatedadulttraumapatientspotentiallyrelatedtotheoccurrenceofventilatorassociatedpneumonia AT abolfazlfiruzian istype2diabetesmellitusinmechanicallyventilatedadulttraumapatientspotentiallyrelatedtotheoccurrenceofventilatorassociatedpneumonia AT ghahramanmahmudi istype2diabetesmellitusinmechanicallyventilatedadulttraumapatientspotentiallyrelatedtotheoccurrenceofventilatorassociatedpneumonia AT melodyomraninava istype2diabetesmellitusinmechanicallyventilatedadulttraumapatientspotentiallyrelatedtotheoccurrenceofventilatorassociatedpneumonia |
_version_ |
1725040997534007296 |