Current Research on Antiepileptic Compounds
Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs....
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doaj-4229f2efa0384a0e9b475688769415f92020-11-24T22:21:29ZengMDPI AGMolecules1420-30492015-11-012011207412077610.3390/molecules201119714molecules201119714Current Research on Antiepileptic CompoundsCheng-Xi Wei0Ming Bian1Guo-Hua Gong2Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, ChinaMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, ChinaMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, ChinaEpilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.http://www.mdpi.com/1420-3049/20/11/19714epilepsyantiepileptic compoundsstructure activity relationship |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng-Xi Wei Ming Bian Guo-Hua Gong |
spellingShingle |
Cheng-Xi Wei Ming Bian Guo-Hua Gong Current Research on Antiepileptic Compounds Molecules epilepsy antiepileptic compounds structure activity relationship |
author_facet |
Cheng-Xi Wei Ming Bian Guo-Hua Gong |
author_sort |
Cheng-Xi Wei |
title |
Current Research on Antiepileptic Compounds |
title_short |
Current Research on Antiepileptic Compounds |
title_full |
Current Research on Antiepileptic Compounds |
title_fullStr |
Current Research on Antiepileptic Compounds |
title_full_unstemmed |
Current Research on Antiepileptic Compounds |
title_sort |
current research on antiepileptic compounds |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2015-11-01 |
description |
Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy. |
topic |
epilepsy antiepileptic compounds structure activity relationship |
url |
http://www.mdpi.com/1420-3049/20/11/19714 |
work_keys_str_mv |
AT chengxiwei currentresearchonantiepilepticcompounds AT mingbian currentresearchonantiepilepticcompounds AT guohuagong currentresearchonantiepilepticcompounds |
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