Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study
Abstract Background The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulation product and liver fat assessed by fatty liver index to the risk of hy...
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doaj-422e7bb68bb44ea0a460654c8e9f854b2020-11-25T03:10:37ZengBMCJournal of Translational Medicine1479-58762019-10-0117111010.1186/s12967-019-2074-1Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based studyXiaolin Huang0Xiaohong Jiang1Long Wang2Lu Chen3Yang Wu4Pei Gao5Fei Hua6Department of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrine and Metabolic Diseases, The Third Affiliated Hospital of Soochow UniversityAbstract Background The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulation product and liver fat assessed by fatty liver index to the risk of hyperuricemia. Methods We conducted a cross-sectional study involving 1284 participants aged ≥ 40 years old recruited from communities in Zhonglou district, Changzhou. Each participant completed a standard questionnaire, and provided blood samples for biochemical measurements. Visceral adiposity index, fatty liver index and lipid accumulation product were calculated by simple anthropometric and functional parameters. Hyperuricemia was defined as serum uric acid ≥ 420 μmol/l for males and ≥ 360 μmol/l for females. Results The prevalence of hyperuricemia was 15.9% and gradually increased across tertiles of adiposity-based indices. The visceral adipose-based measurements (visceral adiposity index, fatty liver index, lipid accumulation product) had better power to discriminate hyperuricemia than body mass index (BMI), waist circumference and neck circumference, and visceral adiposity index exhibited the highest power, with the area under the receiver operating characteristics curve (AUROC) of 0.662 (0.636–0.688). Multivariate logistic regression found 1.49-fold, 2.21-fold and 2.12-fold increased risk of hyperuricemia with 1-unit increment of visceral adiposity index, fatty liver index, and lipid accumulation product, respectively. Compared to tertile 1, the odds ratios of hyperuricemia for the second tertile and the third tertile of visceral adiposity index were 1.57 (1.00–2.50) and 3.11 (1.96–4.94), those of fatty liver index were 1.64 (1.05–2.68) and 3.58 (1.94–6.01), and those of lipid accumulation product were 1.93 (1.19–3.15) and 3.53 (2.05–6.09), respectively. However, no significant associations of BMI, waist circumference and neck circumference with hyperuricemia were observed. Conclusions Visceral adipose accumulation increased the risk of hyperuricemia, independently of BMI, waist circumference and neck circumference, among middle-aged and elderly Chinese adults.http://link.springer.com/article/10.1186/s12967-019-2074-1HyperuricemiaVisceral adiposity indexLipid accumulation productFatty liver indexBody mass indexWaist circumference |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaolin Huang Xiaohong Jiang Long Wang Lu Chen Yang Wu Pei Gao Fei Hua |
spellingShingle |
Xiaolin Huang Xiaohong Jiang Long Wang Lu Chen Yang Wu Pei Gao Fei Hua Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study Journal of Translational Medicine Hyperuricemia Visceral adiposity index Lipid accumulation product Fatty liver index Body mass index Waist circumference |
author_facet |
Xiaolin Huang Xiaohong Jiang Long Wang Lu Chen Yang Wu Pei Gao Fei Hua |
author_sort |
Xiaolin Huang |
title |
Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study |
title_short |
Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study |
title_full |
Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study |
title_fullStr |
Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study |
title_full_unstemmed |
Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study |
title_sort |
visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2019-10-01 |
description |
Abstract Background The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulation product and liver fat assessed by fatty liver index to the risk of hyperuricemia. Methods We conducted a cross-sectional study involving 1284 participants aged ≥ 40 years old recruited from communities in Zhonglou district, Changzhou. Each participant completed a standard questionnaire, and provided blood samples for biochemical measurements. Visceral adiposity index, fatty liver index and lipid accumulation product were calculated by simple anthropometric and functional parameters. Hyperuricemia was defined as serum uric acid ≥ 420 μmol/l for males and ≥ 360 μmol/l for females. Results The prevalence of hyperuricemia was 15.9% and gradually increased across tertiles of adiposity-based indices. The visceral adipose-based measurements (visceral adiposity index, fatty liver index, lipid accumulation product) had better power to discriminate hyperuricemia than body mass index (BMI), waist circumference and neck circumference, and visceral adiposity index exhibited the highest power, with the area under the receiver operating characteristics curve (AUROC) of 0.662 (0.636–0.688). Multivariate logistic regression found 1.49-fold, 2.21-fold and 2.12-fold increased risk of hyperuricemia with 1-unit increment of visceral adiposity index, fatty liver index, and lipid accumulation product, respectively. Compared to tertile 1, the odds ratios of hyperuricemia for the second tertile and the third tertile of visceral adiposity index were 1.57 (1.00–2.50) and 3.11 (1.96–4.94), those of fatty liver index were 1.64 (1.05–2.68) and 3.58 (1.94–6.01), and those of lipid accumulation product were 1.93 (1.19–3.15) and 3.53 (2.05–6.09), respectively. However, no significant associations of BMI, waist circumference and neck circumference with hyperuricemia were observed. Conclusions Visceral adipose accumulation increased the risk of hyperuricemia, independently of BMI, waist circumference and neck circumference, among middle-aged and elderly Chinese adults. |
topic |
Hyperuricemia Visceral adiposity index Lipid accumulation product Fatty liver index Body mass index Waist circumference |
url |
http://link.springer.com/article/10.1186/s12967-019-2074-1 |
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