The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders
Considerable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper re...
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doaj-422f0aa6200e47d08d11427704cc388d2020-12-02T00:01:45ZengMDPI AGJournal of Personalized Medicine2075-44262020-12-011026026010.3390/jpm10040260The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum DisordersEmily L. Casanova0Carolina Baeza-Velasco1Caroline B. Buchanan2Manuel F. Casanova3School of Medicine Greenville, University of South Carolina, Greenville, SC 29615, USADepartment of Psychopathology, Paris Descartes University, LPPS, F-92100 Boulogne-Billancourt, FranceGreenwood Genetic Center, Greenville, SC 29605, USASchool of Medicine Greenville, University of South Carolina, Greenville, SC 29615, USAConsiderable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper reviews our current state of knowledge, as well as highlighting unanswered questions concerning this remarkable patient group, which we hope will attract further scientific interest in coming years. In particular, patients themselves are demanding more research into this growing area of interest, although science has been slow to answer that call. Here, we address the overlap between these two spectrum conditions, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation. Together, these data highlight the potential relatedness of these two conditions and suggest that EDS/HSD may represent a subtype of autism.https://www.mdpi.com/2075-4426/10/4/260autism spectrum disorderEhlers-Danlos syndromehypermobility spectrum disordersautonomic disordermast cell activation syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emily L. Casanova Carolina Baeza-Velasco Caroline B. Buchanan Manuel F. Casanova |
spellingShingle |
Emily L. Casanova Carolina Baeza-Velasco Caroline B. Buchanan Manuel F. Casanova The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders Journal of Personalized Medicine autism spectrum disorder Ehlers-Danlos syndrome hypermobility spectrum disorders autonomic disorder mast cell activation syndrome |
author_facet |
Emily L. Casanova Carolina Baeza-Velasco Caroline B. Buchanan Manuel F. Casanova |
author_sort |
Emily L. Casanova |
title |
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders |
title_short |
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders |
title_full |
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders |
title_fullStr |
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders |
title_full_unstemmed |
The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders |
title_sort |
relationship between autism and ehlers-danlos syndromes/hypermobility spectrum disorders |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2020-12-01 |
description |
Considerable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper reviews our current state of knowledge, as well as highlighting unanswered questions concerning this remarkable patient group, which we hope will attract further scientific interest in coming years. In particular, patients themselves are demanding more research into this growing area of interest, although science has been slow to answer that call. Here, we address the overlap between these two spectrum conditions, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation. Together, these data highlight the potential relatedness of these two conditions and suggest that EDS/HSD may represent a subtype of autism. |
topic |
autism spectrum disorder Ehlers-Danlos syndrome hypermobility spectrum disorders autonomic disorder mast cell activation syndrome |
url |
https://www.mdpi.com/2075-4426/10/4/260 |
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