Enhancement of Binding Affinity of Folate to Its Receptor by Peptide Conjugation

Enhancement of Binding Affinity of Folate to Its Receptor by Peptide Conjugation

(1) Background: The folate receptor (FR) is a target for cancer treatment and detection. Expression of the FR is restricted in normal cells but overexpressed in many types of tumors. Folate was conjugated with peptides for enhancing binding affinity to the FR. (2) Materials and Methods: For conjugat...

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Bibliographic Details
Main Authors: Roopa Dharmatti, Hideyuki Miyatake, Avanashiappan Nandakumar, Motoki Ueda, Kenya Kobayashi, Daisuke Kiga, Masayuki Yamamura, Yoshihiro Ito
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
folate
folate receptor
peptide conjugation
click reaction
biolayer interferometry
Online Access:https://www.mdpi.com/1422-0067/20/9/2152

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