Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocy...

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Main Authors: Lisa Suwandhi, Irem Altun, Ruth Karlina, Viktorian Miok, Tobias Wiedemann, David Fischer, Thomas Walzthoeni, Christina Lindner, Anika Böttcher, Silke S. Heinzmann, Andreas Israel, Ahmed Elagamy Mohamed Mahmoud Khalil, Alexander Braun, Ines Pramme-Steinwachs, Ingo Burtscher, Philippe Schmitt-Kopplin, Matthias Heinig, Martin Elsner, Heiko Lickert, Fabian J. Theis, Siegfried Ussar
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21826-9
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spelling doaj-4238107fca564fd486a026933c82d0542021-03-11T11:32:02ZengNature Publishing GroupNature Communications2041-17232021-03-0112111210.1038/s41467-021-21826-9Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell populationLisa Suwandhi0Irem Altun1Ruth Karlina2Viktorian Miok3Tobias Wiedemann4David Fischer5Thomas Walzthoeni6Christina Lindner7Anika Böttcher8Silke S. Heinzmann9Andreas Israel10Ahmed Elagamy Mohamed Mahmoud Khalil11Alexander Braun12Ines Pramme-Steinwachs13Ingo Burtscher14Philippe Schmitt-Kopplin15Matthias Heinig16Martin Elsner17Heiko Lickert18Fabian J. Theis19Siegfried Ussar20RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichRG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichRG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichGerman Center for Diabetes Research (DZD)German Center for Diabetes Research (DZD)Institute for Computational Biology, Helmholtz Center MunichInstitute for Computational Biology, Helmholtz Center MunichRG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichGerman Center for Diabetes Research (DZD)German Center for Diabetes Research (DZD)RG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichRG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichAnalytical Chemistry and Water Chemistry, Technical University of MunichRG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichGerman Center for Diabetes Research (DZD)German Center for Diabetes Research (DZD)Institute for Computational Biology, Helmholtz Center MunichAnalytical Chemistry and Water Chemistry, Technical University of MunichGerman Center for Diabetes Research (DZD)Institute for Computational Biology, Helmholtz Center MunichRG Adipocytes & Metabolism, Institute for Diabetes and Obesity, Helmholtz Center MunichAdipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocyte population that is enriched in adolescent subcutaneous fat and demonstrate that loss of Asc-1 triggers spontaneous beige adipocyte differentiation.https://doi.org/10.1038/s41467-021-21826-9
collection DOAJ
language English
format Article
sources DOAJ
author Lisa Suwandhi
Irem Altun
Ruth Karlina
Viktorian Miok
Tobias Wiedemann
David Fischer
Thomas Walzthoeni
Christina Lindner
Anika Böttcher
Silke S. Heinzmann
Andreas Israel
Ahmed Elagamy Mohamed Mahmoud Khalil
Alexander Braun
Ines Pramme-Steinwachs
Ingo Burtscher
Philippe Schmitt-Kopplin
Matthias Heinig
Martin Elsner
Heiko Lickert
Fabian J. Theis
Siegfried Ussar
spellingShingle Lisa Suwandhi
Irem Altun
Ruth Karlina
Viktorian Miok
Tobias Wiedemann
David Fischer
Thomas Walzthoeni
Christina Lindner
Anika Böttcher
Silke S. Heinzmann
Andreas Israel
Ahmed Elagamy Mohamed Mahmoud Khalil
Alexander Braun
Ines Pramme-Steinwachs
Ingo Burtscher
Philippe Schmitt-Kopplin
Matthias Heinig
Martin Elsner
Heiko Lickert
Fabian J. Theis
Siegfried Ussar
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
Nature Communications
author_facet Lisa Suwandhi
Irem Altun
Ruth Karlina
Viktorian Miok
Tobias Wiedemann
David Fischer
Thomas Walzthoeni
Christina Lindner
Anika Böttcher
Silke S. Heinzmann
Andreas Israel
Ahmed Elagamy Mohamed Mahmoud Khalil
Alexander Braun
Ines Pramme-Steinwachs
Ingo Burtscher
Philippe Schmitt-Kopplin
Matthias Heinig
Martin Elsner
Heiko Lickert
Fabian J. Theis
Siegfried Ussar
author_sort Lisa Suwandhi
title Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_short Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_full Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_fullStr Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_full_unstemmed Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
title_sort asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the authors identify an Asc-1 positive preadipocyte population that is enriched in adolescent subcutaneous fat and demonstrate that loss of Asc-1 triggers spontaneous beige adipocyte differentiation.
url https://doi.org/10.1038/s41467-021-21826-9
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