Clinical predictors to cognitive impairment in multiple sclerosis patients
Abstract Background Cognitive dysfunction is increasingly recognized in multiple sclerosis, even in the early phase of the disease. Multiple sclerosis patients with even mild cognitive deficits may experience greater difficulties in social contact and daily activities, irrespective of physical handi...
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Online Access: | https://doi.org/10.1186/s41983-021-00292-6 |
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doaj-4238c7a8b32c48b4a548e1866321582c2021-03-11T11:55:34ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292021-03-015711610.1186/s41983-021-00292-6Clinical predictors to cognitive impairment in multiple sclerosis patientsHaidy Elshebawy0Ebtesam Mohamed Fahmy1Nervana Mohamed Elfayoumy2Ahmed Mohamed Abdelalim3Rania Shehata Ismail4Neurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityAbstract Background Cognitive dysfunction is increasingly recognized in multiple sclerosis, even in the early phase of the disease. Multiple sclerosis patients with even mild cognitive deficits may experience greater difficulties in social contact and daily activities, irrespective of physical handicap. This study aimed to estimate clinical predictors of cognitive dysfunction in a sample of Egyptian people with MS. Results Significant worse performance in assessed cognitive scales was observed in people with MS as compared to controls. This was related to low educational level, long disease duration, initial cerebellar and motor attacks, progressive course, frequent relapses, and immunosuppressive medications. Cognitive assessment scales were significantly negatively correlated with disability measured by Expanded Disability Status Scale (EDSS) scores. Conclusion Predictors of cognitive impairment in people with MS were low educational level, longer disease duration, type of initial attack, frequent relapses, progressive form, higher clinical disability, and immunosuppressive treatment.https://doi.org/10.1186/s41983-021-00292-6Multiple sclerosisClinical predictorsCognitive impairment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haidy Elshebawy Ebtesam Mohamed Fahmy Nervana Mohamed Elfayoumy Ahmed Mohamed Abdelalim Rania Shehata Ismail |
spellingShingle |
Haidy Elshebawy Ebtesam Mohamed Fahmy Nervana Mohamed Elfayoumy Ahmed Mohamed Abdelalim Rania Shehata Ismail Clinical predictors to cognitive impairment in multiple sclerosis patients The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Multiple sclerosis Clinical predictors Cognitive impairment |
author_facet |
Haidy Elshebawy Ebtesam Mohamed Fahmy Nervana Mohamed Elfayoumy Ahmed Mohamed Abdelalim Rania Shehata Ismail |
author_sort |
Haidy Elshebawy |
title |
Clinical predictors to cognitive impairment in multiple sclerosis patients |
title_short |
Clinical predictors to cognitive impairment in multiple sclerosis patients |
title_full |
Clinical predictors to cognitive impairment in multiple sclerosis patients |
title_fullStr |
Clinical predictors to cognitive impairment in multiple sclerosis patients |
title_full_unstemmed |
Clinical predictors to cognitive impairment in multiple sclerosis patients |
title_sort |
clinical predictors to cognitive impairment in multiple sclerosis patients |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
issn |
1687-8329 |
publishDate |
2021-03-01 |
description |
Abstract Background Cognitive dysfunction is increasingly recognized in multiple sclerosis, even in the early phase of the disease. Multiple sclerosis patients with even mild cognitive deficits may experience greater difficulties in social contact and daily activities, irrespective of physical handicap. This study aimed to estimate clinical predictors of cognitive dysfunction in a sample of Egyptian people with MS. Results Significant worse performance in assessed cognitive scales was observed in people with MS as compared to controls. This was related to low educational level, long disease duration, initial cerebellar and motor attacks, progressive course, frequent relapses, and immunosuppressive medications. Cognitive assessment scales were significantly negatively correlated with disability measured by Expanded Disability Status Scale (EDSS) scores. Conclusion Predictors of cognitive impairment in people with MS were low educational level, longer disease duration, type of initial attack, frequent relapses, progressive form, higher clinical disability, and immunosuppressive treatment. |
topic |
Multiple sclerosis Clinical predictors Cognitive impairment |
url |
https://doi.org/10.1186/s41983-021-00292-6 |
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