CD80 and CD86 expression in nasopharyngeal carcinoma and their correlation with recurrence after endoscopic sinus surgery as well as tumor invasion and apoptosis

• Main Authors: Shuang Ji1, Jun Feng1, Xiao-Li Zeng2
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Nasopharyngeal carcinoma CD80 CD86 Apoptosis Invasion
• Online Access: http://www.hnykdxxb.com/PDF/201710/24.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study CD80 and CD86 expression in nasopharyngeal carcinoma and their correlation with recurrence after endoscopic sinus surgery as well as tumor invasion and apoptosis. Methods: Patients with nasopharyngeal carcinoma who received surgical resection in Nanchong Central Hospital between February 2013 and March 2014 were collected and divided into recurrence group and non-recurrence group according to the recurrence 3 years after surgery. Normal nasal mucosa tissue for biopsy during the same period was collected, and the expression levels of CD80, CD86 as well as apoptosis molecules and invasion molecules in lesions were detected. Results: CD80, ARD1, Survivin, Shh, Ptch1, S100A4, Ezrin and N-cadherin expression in lesions of recurrence group and non-recurrence group were significantly higher than those of control group, and CD80, ARD1, Survivin, Shh, Ptch1, S100A4, Ezrin and N-cadherin expression in lesions of recurrence group were significantly higher than those of non-recurrence group; CD86 expression in lesions were not significantly different among recurrence group, non-recurrence group and control group. ARD1, Survivin, Shh, Ptch1, S100A4, Ezrin and N-cadherin mRNA expression in nasopharyngeal carcinoma lesions with high CD80 expression were significantly higher than those in nasopharyngeal carcinoma lesions with low CD80 expression. Conclusion: The high expression of CD80 in nasopharyngeal carcinoma can participate in tumor recurrence through promoting the cell proliferation and invasion.