Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism
Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-in...
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Tehran University of Medical Sciences
2014-02-01
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doaj-425335f620d244a08c4f03172e9c65402020-11-25T04:12:00ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492014-02-01131447Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent MechanismGuqin Zhang0Jiong Yang1Ping Li2Jie Cao3Hanxiang Nie4Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, ChinaDepartment of Respiratory Medicine, Zhongnan Hospital of Wuhan University, ChinaDepartment of Respiratory Medicine, Zhongnan Hospital of Wuhan University, ChinaDepartment of Respiratory Medicine, Zhongnan Hospital of Wuhan University, ChinaDepartment of Respiratory Medicine, Renmin Hospital of Wuhan University, China Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response. To investigate a possible role for PPARγ in human mast cells, we studied the effects of a PPARγ ligand, rosiglitazone (RG), on stem cell factor (SCF)-induced migration and fibronectin-induced adhesion in human mast cell-1(HMC-1) cells. It was found that HMC-1 cells expressed PPARγ mRNA. RG inhibited SCF-induced HMC-1 cell migration and fibronectin-induced HMC-1 cell adhesion, the selective PPARγ antagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells. In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/482AdhesionMast cellsMigrationPPARγRosiglitazone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guqin Zhang Jiong Yang Ping Li Jie Cao Hanxiang Nie |
spellingShingle |
Guqin Zhang Jiong Yang Ping Li Jie Cao Hanxiang Nie Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism Iranian Journal of Allergy, Asthma and Immunology Adhesion Mast cells Migration PPARγ Rosiglitazone |
author_facet |
Guqin Zhang Jiong Yang Ping Li Jie Cao Hanxiang Nie |
author_sort |
Guqin Zhang |
title |
Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism |
title_short |
Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism |
title_full |
Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism |
title_fullStr |
Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism |
title_full_unstemmed |
Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism |
title_sort |
rosiglitazone inhibits hmc-1 cell migration and adhesion through a peroxisome proliferator-activated receptor gamma-dependent mechanism |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2014-02-01 |
description |
Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response.
To investigate a possible role for PPARγ in human mast cells, we studied the effects of a
PPARγ ligand, rosiglitazone (RG), on stem cell factor (SCF)-induced migration and fibronectin-induced adhesion in human mast cell-1(HMC-1) cells.
It was found that HMC-1 cells expressed PPARγ mRNA. RG inhibited SCF-induced HMC-1 cell migration and fibronectin-induced HMC-1 cell adhesion, the selective PPARγ antagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells.
In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism.
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topic |
Adhesion Mast cells Migration PPARγ Rosiglitazone |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/482 |
work_keys_str_mv |
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