Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade antifúngica e inibidora de acetilcolinesterase

• Main Authors: Lisinéia M. Zanardi, Vanderlan da S. Bolzani, Alberto J. Cavalheiro, Dulce H. Siqueira Silva, Henrique C. Trevisan, Angela R. Araujo, Geraldo H. Silva, Helder L. Teles, Maria Cláudia M. Young
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2012-01-01
• Series: Química Nova
• Subjects: Phomopsis cassia; endophytic fungus; sesquiterpenes
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100026&lng=en&tlng=en

SESQUITERPENES PRODUCED BY ENDOPHYTIC FUNGUS Phomopsis cassiae WITH ANTIFUNGAL AND ACETYLCHOLINESTERASE INHIBITION ACTIVITIES. Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, including relative stereochemistry, were determined on the basis of detailed interpretation of 2D NMR spectra and comparison with related known compounds. Compounds 1-4 displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as inhibition of acetylcholinesterase.