Advances in the study of macrophages in wound healing

• Main Authors: Yu-Lian Yin, Pan Ling-Ting, Yi-Qin Cheng, Hong-Feng Chen
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-08-01
• Series: Journal of Hainan Medical University
• Subjects: macrophage; phenotypic transformation; regulatory mechanism
• Online Access: http://www.hnykdxxb.com/PDF/201915/16.pdf

Macrophages are a group of immune cells with highly heterogeneous phenotypes and functions, which run through the whole process of tissue repair. Macrophages are distributed in various organs and tissues of the body, which are a kind of cell population with plasticity and high heterogeneity in the functional state. Under various conditions, it can be transformed into M1-type (classically activated macrophage) and M2-type macrophages (alternatively activated macrophage).It was also found that the phenotypic polarization of macrophages was regulated by a variety of conditions. This review summarizes the existing studies on the effect of macrophage subtypes on wound repair and the mechanism of regulating macrophage phenotype polarization, so as to provide theoretical basis for further studies.