Inner ear delivery: Challenges and opportunities

Abstract Objectives The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation. Da...

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Main Authors:	Betsy Szeto, Harry Chiang, Chris Valentini, Michelle Yu, Jeffrey W. Kysar, Anil K. Lalwani
Format:	Article
Language:	English
Published:	Wiley 2020-02-01
Series:	Laryngoscope Investigative Otolaryngology
Subjects:	inner ear disorders intracochlear delivery microneedles nanoparticles
Online Access:	https://doi.org/10.1002/lio2.336

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record_format	Article
spelling	doaj-428584ac7e5844f990242b16c1ab5d362020-11-25T03:43:04ZengWileyLaryngoscope Investigative Otolaryngology2378-80382020-02-015112213110.1002/lio2.336Inner ear delivery: Challenges and opportunitiesBetsy Szeto0Harry Chiang1Chris Valentini2Michelle Yu3Jeffrey W. Kysar4Anil K. Lalwani5Department of Otolaryngology–Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons New York New YorkDepartment of Otolaryngology–Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons New York New YorkDepartment of Otolaryngology–Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons New York New YorkDepartment of Otolaryngology–Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons New York New YorkDepartment of Otolaryngology–Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons New York New YorkDepartment of Otolaryngology–Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons New York New YorkAbstract Objectives The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation. Data Sources The databases used were PubMed, EMBASE, and Web of Science. Results Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants. Conclusions In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation. Level of Evidence NAhttps://doi.org/10.1002/lio2.336inner ear disordersintracochlear deliverymicroneedlesnanoparticles
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Betsy Szeto Harry Chiang Chris Valentini Michelle Yu Jeffrey W. Kysar Anil K. Lalwani
spellingShingle	Betsy Szeto Harry Chiang Chris Valentini Michelle Yu Jeffrey W. Kysar Anil K. Lalwani Inner ear delivery: Challenges and opportunities Laryngoscope Investigative Otolaryngology inner ear disorders intracochlear delivery microneedles nanoparticles
author_facet	Betsy Szeto Harry Chiang Chris Valentini Michelle Yu Jeffrey W. Kysar Anil K. Lalwani
author_sort	Betsy Szeto
title	Inner ear delivery: Challenges and opportunities
title_short	Inner ear delivery: Challenges and opportunities
title_full	Inner ear delivery: Challenges and opportunities
title_fullStr	Inner ear delivery: Challenges and opportunities
title_full_unstemmed	Inner ear delivery: Challenges and opportunities
title_sort	inner ear delivery: challenges and opportunities
publisher	Wiley
series	Laryngoscope Investigative Otolaryngology
issn	2378-8038
publishDate	2020-02-01
description	Abstract Objectives The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation. Data Sources The databases used were PubMed, EMBASE, and Web of Science. Results Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants. Conclusions In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation. Level of Evidence NA
topic	inner ear disorders intracochlear delivery microneedles nanoparticles
url	https://doi.org/10.1002/lio2.336
work_keys_str_mv	AT betsyszeto innereardeliverychallengesandopportunities AT harrychiang innereardeliverychallengesandopportunities AT chrisvalentini innereardeliverychallengesandopportunities AT michelleyu innereardeliverychallengesandopportunities AT jeffreywkysar innereardeliverychallengesandopportunities AT anilklalwani innereardeliverychallengesandopportunities
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Inner ear delivery: Challenges and opportunities

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