Inflammatory Cytokine TSLP Stimulates Platelet Secretion and Potentiates Platelet Aggregation via a TSLPR-Dependent PI3K/Akt Signaling Pathway

Inflammatory Cytokine TSLP Stimulates Platelet Secretion and Potentiates Platelet Aggregation via a TSLPR-Dependent PI3K/Akt Signaling Pathway

Aims: Thymic stromal lymphopoietin (TSLP) plays an important role in inflammatory diseases and is over-expressed in human atherosclerotic artery specimens. The present study investigated the role of TSLP in platelet activation and thrombosis models in vitro and in vivo, as well as the underlying mec...

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Bibliographic Details
Main Authors: Jangchuan Dong, Jing Lin, Boyuan Wang, Shaolin He, Chun Wu, Kishan Kumar Kushwaha, Nilesh Mohabeer, Yousu Su, Hongcheng Fang, Kai Huang, Dazhu Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Thymic stromal lymphopoietin
Platelet activation
Thrombus formation
PI3K/Akt signaling
Online Access:http://www.karger.com/Article/FullText/369684

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http://www.karger.com/Article/FullText/369684

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