Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients
Background/Aims: Heart rate variability (HRV) has been linked to mortality in maintenance hemodialysis (HD) patients, but it is less clear whether HRV is associated with major adverse cardiovascular events (MACEs) and hospitalization. Methods: This study enrolled 179 maintenance HD patients. HRV was...
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2017-03-01
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doaj-4289934bc56443ab95f03bdd20e016e42020-11-25T03:51:55ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432017-03-01421768810.1159/000469716469716Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis PatientsJiun-Chi HuangI-Ching KuoYi-Chun TsaiJia-Jung LeeLee-Moay LimSzu-Chia ChenYi-Wen ChiuJer-Ming ChangHung-hun ChenBackground/Aims: Heart rate variability (HRV) has been linked to mortality in maintenance hemodialysis (HD) patients, but it is less clear whether HRV is associated with major adverse cardiovascular events (MACEs) and hospitalization. Methods: This study enrolled 179 maintenance HD patients. HRV was measured to assess its prognostic significance in relation to MACEs and hospitalization. Results: During the follow-up period of 33.3 ± 6.7 months, 36 (20.1%) patients had a MACE, and 98 (54.7%) experienced hospitalization. In multivariate adjusted Cox regression analysis, low very low frequency (VLF) power (hazard ratio [HR], 0.727; 95% confidence interval [CI], 0.624–0.848; p < 0.001), a history of coronary artery disease, high ultrafiltration rate, the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, and the use of beta-blockers were all significantly associated with MACEs. Low VLF power (HR, 0.873; 95% CI, 0.785–0.971; p = 0.012), low serum albumin, low serum creatinine, low Kt/V levels, and high serum calcium-phosphorus product levels significantly predicted hospitalization in maintenance HD patients. Conclusions: Reduced VLF power is linked to an increased risk of MACEs and hospitalization in maintenance HD patients. Assessing cardiac autonomic function through HRV is of pivotal prognostic significance for this patient population.http://www.karger.com/Article/FullText/469716HospitalizationVery low frequencyHemodialysisMajor adverse cardiovascular eventsHeart rate variability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiun-Chi Huang I-Ching Kuo Yi-Chun Tsai Jia-Jung Lee Lee-Moay Lim Szu-Chia Chen Yi-Wen Chiu Jer-Ming Chang Hung-hun Chen |
spellingShingle |
Jiun-Chi Huang I-Ching Kuo Yi-Chun Tsai Jia-Jung Lee Lee-Moay Lim Szu-Chia Chen Yi-Wen Chiu Jer-Ming Chang Hung-hun Chen Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients Kidney & Blood Pressure Research Hospitalization Very low frequency Hemodialysis Major adverse cardiovascular events Heart rate variability |
author_facet |
Jiun-Chi Huang I-Ching Kuo Yi-Chun Tsai Jia-Jung Lee Lee-Moay Lim Szu-Chia Chen Yi-Wen Chiu Jer-Ming Chang Hung-hun Chen |
author_sort |
Jiun-Chi Huang |
title |
Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients |
title_short |
Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients |
title_full |
Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients |
title_fullStr |
Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients |
title_full_unstemmed |
Heart Rate Variability Predicts Major Adverse Cardiovascular Events and Hospitalization in Maintenance Hemodialysis Patients |
title_sort |
heart rate variability predicts major adverse cardiovascular events and hospitalization in maintenance hemodialysis patients |
publisher |
Karger Publishers |
series |
Kidney & Blood Pressure Research |
issn |
1420-4096 1423-0143 |
publishDate |
2017-03-01 |
description |
Background/Aims: Heart rate variability (HRV) has been linked to mortality in maintenance hemodialysis (HD) patients, but it is less clear whether HRV is associated with major adverse cardiovascular events (MACEs) and hospitalization. Methods: This study enrolled 179 maintenance HD patients. HRV was measured to assess its prognostic significance in relation to MACEs and hospitalization. Results: During the follow-up period of 33.3 ± 6.7 months, 36 (20.1%) patients had a MACE, and 98 (54.7%) experienced hospitalization. In multivariate adjusted Cox regression analysis, low very low frequency (VLF) power (hazard ratio [HR], 0.727; 95% confidence interval [CI], 0.624–0.848; p < 0.001), a history of coronary artery disease, high ultrafiltration rate, the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, and the use of beta-blockers were all significantly associated with MACEs. Low VLF power (HR, 0.873; 95% CI, 0.785–0.971; p = 0.012), low serum albumin, low serum creatinine, low Kt/V levels, and high serum calcium-phosphorus product levels significantly predicted hospitalization in maintenance HD patients. Conclusions: Reduced VLF power is linked to an increased risk of MACEs and hospitalization in maintenance HD patients. Assessing cardiac autonomic function through HRV is of pivotal prognostic significance for this patient population. |
topic |
Hospitalization Very low frequency Hemodialysis Major adverse cardiovascular events Heart rate variability |
url |
http://www.karger.com/Article/FullText/469716 |
work_keys_str_mv |
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