Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease

Cognitive dysfunction is a significant non-motor feature of Parkinson's disease, with the risk of dementia increasing with prolonged disease duration. Multiple cognitive domains are affected, and the pathophysiology cannot be explained by dopaminergic loss alone. Sophisticated neuroimaging tech...

Full description

Bibliographic Details
Main Authors:	Sanskriti Sasikumar, Antonio P. Strafella
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-01-01
Series:	Frontiers in Neurology
Subjects:	mild cognitive impairment dementia Parkinson's disease biomarker imaging
Online Access:	https://www.frontiersin.org/article/10.3389/fneur.2020.00047/full

id	doaj-4289936563e34d17819a843eecc8c8d3
record_format	Article
spelling	doaj-4289936563e34d17819a843eecc8c8d32020-11-25T02:21:53ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-01-011110.3389/fneur.2020.00047511290Imaging Mild Cognitive Impairment and Dementia in Parkinson's DiseaseSanskriti Sasikumar0Antonio P. Strafella1Antonio P. Strafella2Antonio P. Strafella3Antonio P. Strafella4Division of Neurology, University of Toronto, Toronto, ON, CanadaDivision of Neurology, University of Toronto, Toronto, ON, CanadaMorton and Gloria Shulman Movement Disorder Unit & E. J. Safra Parkinson Disease Program, Neurology Division, Department of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, CanadaResearch Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, University of Toronto, Toronto, ON, CanadaDivision of Brain, Imaging and Behaviour – Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Toronto, ON, CanadaCognitive dysfunction is a significant non-motor feature of Parkinson's disease, with the risk of dementia increasing with prolonged disease duration. Multiple cognitive domains are affected, and the pathophysiology cannot be explained by dopaminergic loss alone. Sophisticated neuroimaging techniques can detect the nature and extent of extra-nigral involvement by targeting neurotransmitters, abnormal protein aggregates and tissue metabolism. This review identifies the functional and anatomical imaging characteristics that predict cognitive impairment in PD, the limitations that challenge this process, and the avenues of potential research.https://www.frontiersin.org/article/10.3389/fneur.2020.00047/fullmild cognitive impairmentdementiaParkinson's diseasebiomarkerimaging
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sanskriti Sasikumar Antonio P. Strafella Antonio P. Strafella Antonio P. Strafella Antonio P. Strafella
spellingShingle	Sanskriti Sasikumar Antonio P. Strafella Antonio P. Strafella Antonio P. Strafella Antonio P. Strafella Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease Frontiers in Neurology mild cognitive impairment dementia Parkinson's disease biomarker imaging
author_facet	Sanskriti Sasikumar Antonio P. Strafella Antonio P. Strafella Antonio P. Strafella Antonio P. Strafella
author_sort	Sanskriti Sasikumar
title	Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease
title_short	Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease
title_full	Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease
title_fullStr	Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease
title_full_unstemmed	Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease
title_sort	imaging mild cognitive impairment and dementia in parkinson's disease
publisher	Frontiers Media S.A.
series	Frontiers in Neurology
issn	1664-2295
publishDate	2020-01-01
description	Cognitive dysfunction is a significant non-motor feature of Parkinson's disease, with the risk of dementia increasing with prolonged disease duration. Multiple cognitive domains are affected, and the pathophysiology cannot be explained by dopaminergic loss alone. Sophisticated neuroimaging techniques can detect the nature and extent of extra-nigral involvement by targeting neurotransmitters, abnormal protein aggregates and tissue metabolism. This review identifies the functional and anatomical imaging characteristics that predict cognitive impairment in PD, the limitations that challenge this process, and the avenues of potential research.
topic	mild cognitive impairment dementia Parkinson's disease biomarker imaging
url	https://www.frontiersin.org/article/10.3389/fneur.2020.00047/full
work_keys_str_mv	AT sanskritisasikumar imagingmildcognitiveimpairmentanddementiainparkinsonsdisease AT antoniopstrafella imagingmildcognitiveimpairmentanddementiainparkinsonsdisease AT antoniopstrafella imagingmildcognitiveimpairmentanddementiainparkinsonsdisease AT antoniopstrafella imagingmildcognitiveimpairmentanddementiainparkinsonsdisease AT antoniopstrafella imagingmildcognitiveimpairmentanddementiainparkinsonsdisease
_version_	1724864891536277504

Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease

Similar Items