Risk or Protective Factors of Prostate Cancer Progressing to Castration Resistant Prostate Cancer After Androgen Deprivation Therapy

• Main Authors: CHEN Chiwei, LIN Mandi, LIU Hao, ZHU Lujun, ZENG Haiping, WANG Zhigang, WANG Jun, CHEN Ming
• Format: Article
• Language: zho
• Published: Magazine House of Cancer Research on Prevention and Treatment 2020-07-01
• Series: Zhongliu Fangzhi Yanjiu
• Subjects: castration-resistant prostate cancer; risk factors; protective factors; survival analysis; logistic regression analysis
• Online Access: http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.1440.htm
• ISSN: 1000-8578; 1000-8578

Objective To screen the possible risk factors and protective factors for prostate cancer early (in 2 years)progressing to castration resistant prostate cancer (CRPC). Methods A total of 71 patients who had progressed to CRPC in 2 years were classified as case group and 71 patients without progressing to CRPC in 2 years were classified as control group. Logistic regression analysis and survival analysis were applied to screen the risk or protective factors. Results PSA nadir and Time to PSA nadir (TTN) were statistically significant between case group and control group in logistic regression analysis (P < 0.05). Median CRPC occurrence time was 8.29 and 16 months in TTN≤9 months group and TTN > 9 months group, respectively. Median CRPC occurrence time was 12 and 9 months in PSA nadir≤0.2 ng/ml group and PSA nadir > 0.2 ng/ml group, respectively. Conclusion TTN may be a protective factor and PSA nadir may be an independent risk factor for prostate cancer early progressing to CRPC. TTN≤9 months and PSA nadir > 0.2 ng/ml are the risk factors of CRPC.