A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation From Immunogenicity

A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation From Immunogenicity

Background. Group B Neisseria meningitidis, an endotoxin-producing gram-negative bacterium, causes the highest incidence of group B meningococcus (MenB) disease in the first year of life. The Bexsero vaccine is indicated in Europe from 8 weeks of age. Endotoxin components of outer membrane vesicles...

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Bibliographic Details
Main Authors: David J. Dowling, Holly Sanders, Wing Ki Cheng, Sweta Joshi, Spencer Brightman, Ilana Bergelson, Carlo Pietrasanta, Simon Daniel Van Haren, Sandra van Amsterdam, Jeffrey Fernandez, Germie P.J.M. van den Dobbelsteen, Ofer Levy
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Vaccine
Newborn
dendritic cells.
outer membrane vesicles
Group B meningococci
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00562/full

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