The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples
The predominant activity of slow wave sleep is cortical slow oscillations (SOs), thalamic spindles and hippocampal sharp wave ripples. While the precise temporal nesting of these rhythms was shown to be essential for memory consolidation, the coordination mechanism is poorly understood. Here we deve...
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doaj-42a3da693de649c4874ffa6ab26b86522021-10-05T04:18:39ZengElsevierNeuroImage1095-95722021-11-01243118485The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripplesAmin Azimi0Zahra Alizadeh1Maryam Ghorbani2Department of Physics, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran, Postal code: 45137-66731Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran, Postal code: 9177948974Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran, Postal code: 9177948974; Rayan Center for Neuroscience and Behavior, Ferdowsi University of Mashhad, Mashhad, Iran, Postal code: 9177948974; Corresponding author.The predominant activity of slow wave sleep is cortical slow oscillations (SOs), thalamic spindles and hippocampal sharp wave ripples. While the precise temporal nesting of these rhythms was shown to be essential for memory consolidation, the coordination mechanism is poorly understood. Here we develop a minimal hippocampo-cortico-thalamic network that can explain the mechanism underlying the SO-spindle-ripple coupling indicating of the succession of regional neuronal interactions. Further we verify the model predictions experimentally in naturally sleeping rodents showing our simple model provides a quantitative match to several experimental observations including the nesting of ripples in the spindle troughs and larger duration but lower amplitude of the ripples co-occurring with spindles or SOs compared to the isolated ripples. The model also predicts that the coupling of ripples to SOs and spindles monotonically enhances by increasing the strength of hippocampo-cortical connections while it is stronger at intermediate values of the cortico-hippocampal projections.http://www.sciencedirect.com/science/article/pii/S1053811921007588Phase-amplitude couplingSleep spindlesNeural mass modelSharp wave ripples |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amin Azimi Zahra Alizadeh Maryam Ghorbani |
spellingShingle |
Amin Azimi Zahra Alizadeh Maryam Ghorbani The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples NeuroImage Phase-amplitude coupling Sleep spindles Neural mass model Sharp wave ripples |
author_facet |
Amin Azimi Zahra Alizadeh Maryam Ghorbani |
author_sort |
Amin Azimi |
title |
The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples |
title_short |
The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples |
title_full |
The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples |
title_fullStr |
The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples |
title_full_unstemmed |
The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples |
title_sort |
essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2021-11-01 |
description |
The predominant activity of slow wave sleep is cortical slow oscillations (SOs), thalamic spindles and hippocampal sharp wave ripples. While the precise temporal nesting of these rhythms was shown to be essential for memory consolidation, the coordination mechanism is poorly understood. Here we develop a minimal hippocampo-cortico-thalamic network that can explain the mechanism underlying the SO-spindle-ripple coupling indicating of the succession of regional neuronal interactions. Further we verify the model predictions experimentally in naturally sleeping rodents showing our simple model provides a quantitative match to several experimental observations including the nesting of ripples in the spindle troughs and larger duration but lower amplitude of the ripples co-occurring with spindles or SOs compared to the isolated ripples. The model also predicts that the coupling of ripples to SOs and spindles monotonically enhances by increasing the strength of hippocampo-cortical connections while it is stronger at intermediate values of the cortico-hippocampal projections. |
topic |
Phase-amplitude coupling Sleep spindles Neural mass model Sharp wave ripples |
url |
http://www.sciencedirect.com/science/article/pii/S1053811921007588 |
work_keys_str_mv |
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