Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research

Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research

Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and...

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Bibliographic Details
Main Authors: Melanie J. Grubisha, Robert A. Sweet, Matthew L. MacDonald
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
proteomics
post-translational modification
schizophrenia
psychiatric disease
autism
post-mortem brain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.689495/full
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spelling doaj-42a801ed1be64c49abb4f8ea2c0904632021-07-16T05:45:01ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-07-011410.3389/fnmol.2021.689495689495Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain ResearchMelanie J. Grubisha0Robert A. Sweet1Matthew L. MacDonald2Matthew L. MacDonald3Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United StatesBiomedical Mass Spectrometry Center, University of Pittsburgh, Pittsburgh, PA, United StatesGene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.https://www.frontiersin.org/articles/10.3389/fnmol.2021.689495/fullproteomicspost-translational modificationschizophreniapsychiatric diseaseautismpost-mortem brain
collection DOAJ
language English
format Article
sources DOAJ
author Melanie J. Grubisha
Robert A. Sweet
Matthew L. MacDonald
Matthew L. MacDonald
spellingShingle Melanie J. Grubisha
Robert A. Sweet
Matthew L. MacDonald
Matthew L. MacDonald
Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
Frontiers in Molecular Neuroscience
proteomics
post-translational modification
schizophrenia
psychiatric disease
autism
post-mortem brain
author_facet Melanie J. Grubisha
Robert A. Sweet
Matthew L. MacDonald
Matthew L. MacDonald
author_sort Melanie J. Grubisha
title Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
title_short Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
title_full Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
title_fullStr Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
title_full_unstemmed Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
title_sort investigating post-translational modifications in neuropsychiatric disease: the next frontier in human post-mortem brain research
publisher Frontiers Media S.A.
series Frontiers in Molecular Neuroscience
issn 1662-5099
publishDate 2021-07-01
description Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.
topic proteomics
post-translational modification
schizophrenia
psychiatric disease
autism
post-mortem brain
url https://www.frontiersin.org/articles/10.3389/fnmol.2021.689495/full
work_keys_str_mv AT melaniejgrubisha investigatingposttranslationalmodificationsinneuropsychiatricdiseasethenextfrontierinhumanpostmortembrainresearch
AT robertasweet investigatingposttranslationalmodificationsinneuropsychiatricdiseasethenextfrontierinhumanpostmortembrainresearch
AT matthewlmacdonald investigatingposttranslationalmodificationsinneuropsychiatricdiseasethenextfrontierinhumanpostmortembrainresearch
AT matthewlmacdonald investigatingposttranslationalmodificationsinneuropsychiatricdiseasethenextfrontierinhumanpostmortembrainresearch
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