Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury
Introduction. Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase of IR are not well understood.Objective. The aim was to investigate this question.Mate...
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doaj-42ab4f9809cb4b2987bf0f78ebba06072021-06-09T05:54:28ZengElsevierAnnals of Hepatology1665-26812013-01-01121130137Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injuryHeleen A.H. de Vries0Fraukje A.M. Ponds1Vincent B. Nieuwenhuijs2Arthur Morphett3Robert T.A. Padbury4Greg J. Barritt5Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia, Australia; The HPB and Liver Transplant Unit, Flinders Medical Centre, Adelaide, South Australia, AustraliaDepartment of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia, Australia; The HPB and Liver Transplant Unit, Flinders Medical Centre, Adelaide, South Australia, AustraliaDepartment of Surgery, University Medical Centre, Groningen, The NetherlandsDepartment of Anatomical Pathology, Flinders Medical Centre, Adelaide, South Australia, AustraliaThe HPB and Liver Transplant Unit, Flinders Medical Centre, Adelaide, South Australia, AustraliaDepartment of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia, Australia; Correspondence and reprint request:Introduction. Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase of IR are not well understood.Objective. The aim was to investigate this question.Material and methods. A rat model of segmental hepatic ischemia was employed. Rats were pre-treated with the estrogen receptor antagonist ICI182,780 and/or the estrogen receptor agonist 17β-estradiol. Bile flow, blood concentrations of bilirubin and liver enzymes were measured, and liver histology was assessed.Results. Bile flow recovery immediately after the initiation of reperfusion was faster in females than in males. ICI182,780 reduced the rate of bile flow recovery in females but this reduction was not reversed by co-administration of 17 β-estradiol. In males, 17 β-estradiol alone did not enhance bile flow recovery. The changes in bile flow recovery observed under a given condition were correlated with small changes in blood liver enzymes and liver histology.Conclusions. Sex has a significant influence on the early recovery of liver function in the acute phase of IR injury. However, in female rats estrogen receptors play only a limited role in mediating enhanced recovery of liver function.http://www.sciencedirect.com/science/article/pii/S166526811931395XHepatic damageBlood liver enzymesBilirubinSex17 beta-estradiole |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heleen A.H. de Vries Fraukje A.M. Ponds Vincent B. Nieuwenhuijs Arthur Morphett Robert T.A. Padbury Greg J. Barritt |
spellingShingle |
Heleen A.H. de Vries Fraukje A.M. Ponds Vincent B. Nieuwenhuijs Arthur Morphett Robert T.A. Padbury Greg J. Barritt Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury Annals of Hepatology Hepatic damage Blood liver enzymes Bilirubin Sex 17 beta-estradiole |
author_facet |
Heleen A.H. de Vries Fraukje A.M. Ponds Vincent B. Nieuwenhuijs Arthur Morphett Robert T.A. Padbury Greg J. Barritt |
author_sort |
Heleen A.H. de Vries |
title |
Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury |
title_short |
Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury |
title_full |
Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury |
title_fullStr |
Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury |
title_full_unstemmed |
Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury |
title_sort |
evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2013-01-01 |
description |
Introduction. Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase of IR are not well understood.Objective. The aim was to investigate this question.Material and methods. A rat model of segmental hepatic ischemia was employed. Rats were pre-treated with the estrogen receptor antagonist ICI182,780 and/or the estrogen receptor agonist 17β-estradiol. Bile flow, blood concentrations of bilirubin and liver enzymes were measured, and liver histology was assessed.Results. Bile flow recovery immediately after the initiation of reperfusion was faster in females than in males. ICI182,780 reduced the rate of bile flow recovery in females but this reduction was not reversed by co-administration of 17 β-estradiol. In males, 17 β-estradiol alone did not enhance bile flow recovery. The changes in bile flow recovery observed under a given condition were correlated with small changes in blood liver enzymes and liver histology.Conclusions. Sex has a significant influence on the early recovery of liver function in the acute phase of IR injury. However, in female rats estrogen receptors play only a limited role in mediating enhanced recovery of liver function. |
topic |
Hepatic damage Blood liver enzymes Bilirubin Sex 17 beta-estradiole |
url |
http://www.sciencedirect.com/science/article/pii/S166526811931395X |
work_keys_str_mv |
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