Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure

The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form...

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Main Authors:	Yu. P. Kovalchuk, I. V. Prischepa, U. Si, V. S. Nedzvetsky, Y. G. Kot, E. E. Persky, G. A. Ushakova
Format:	Article
Language:	English
Published:	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2015-06-01
Series:	Ukrainian Biochemical Journal
Subjects:	cadmium glial fibrillary acid protein rat brain
Online Access:	http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kovalchuk_3_15.pdf

id	doaj-42c56bce65384eb8811c789bb0b1ba50
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spelling	doaj-42c56bce65384eb8811c789bb0b1ba502020-11-24T22:42:52ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Ukrainian Biochemical Journal2409-49432413-50032015-06-0187311612310.15407/ubj87.03.116Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposureYu. P. Kovalchuk0I. V. Prischepa1U. Si2V. S. Nedzvetsky3Y. G. Kot4E. E. Persky5G. A. Ushakova6Oles’ Honchar Dnepropetrovsk National University, UkraineOles’ Honchar Dnepropetrovsk National University, Ukraine V. N. Karazin Kharkiv National University, UkraineOles’ Honchar Dnepropetrovsk National University, UkraineV. N. Karazin Kharkiv National University, UkraineV. N. Karazin Kharkiv National University, UkraineOles’ Honchar Dnepropetrovsk National University, UkraineThe chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 µg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration.http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kovalchuk_3_15.pdfcadmiumglial fibrillary acid proteinrat brain
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yu. P. Kovalchuk I. V. Prischepa U. Si V. S. Nedzvetsky Y. G. Kot E. E. Persky G. A. Ushakova
spellingShingle	Yu. P. Kovalchuk I. V. Prischepa U. Si V. S. Nedzvetsky Y. G. Kot E. E. Persky G. A. Ushakova Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure Ukrainian Biochemical Journal cadmium glial fibrillary acid protein rat brain
author_facet	Yu. P. Kovalchuk I. V. Prischepa U. Si V. S. Nedzvetsky Y. G. Kot E. E. Persky G. A. Ushakova
author_sort	Yu. P. Kovalchuk
title	Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
title_short	Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
title_full	Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
title_fullStr	Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
title_full_unstemmed	Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
title_sort	distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure
publisher	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
series	Ukrainian Biochemical Journal
issn	2409-4943 2413-5003
publishDate	2015-06-01
description	The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 µg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration.
topic	cadmium glial fibrillary acid protein rat brain
url	http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kovalchuk_3_15.pdf
work_keys_str_mv	AT yupkovalchuk distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure AT ivprischepa distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure AT usi distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure AT vsnedzvetsky distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure AT ygkot distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure AT eepersky distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure AT gaushakova distributionofglialfibrillaryacidicproteinindifferentpartsoftheratbrainundercadmiumexposure
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Distribution of glial fibrillary acidic protein in different parts of the rat brain under cadmium exposure

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