Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model
Objective: In assisted reproductive technology, it is important to choose high quality embryos for embryo transfer. The aim of the present study was to determine the grade A embryo count and factors related to it in infertile women. Materials and Methods: This historical cohort study included 996...
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doaj-42cd09d075a64a4596b7779e1d338af62020-11-25T02:29:01ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142017-08-0119350651110.22074/cellj.2017.4214.Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression ModelAmir Almasi-Hashiani0Azadeh Ghaheri1Reza Omani Samani2Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranObjective: In assisted reproductive technology, it is important to choose high quality embryos for embryo transfer. The aim of the present study was to determine the grade A embryo count and factors related to it in infertile women. Materials and Methods: This historical cohort study included 996 infertile women. The main outcome was the number of grade A embryos. Zero-Inflated Poisson (ZIP) regression and Zero-Inflated Negative Binomial (ZINB) regression were used to model the count data as it contained excessive zeros. Stata software, version 13 (Stata Corp, College Station, TX, USA) was used for all statistical analyses. Results: After adjusting for potential confounders, results from the ZINB model show that for each unit increase in the number 2 pronuclear (2PN) zygotes, we get an increase of 1.45 times as incidence rate ratio (95% confidence interval (CI): 1.23-1.69, P=0.001) in the expected grade A embryo count number, and for each increase in the cleavage day we get a decrease 0.35 times (95% CI: 0.20-0.61, P=0.001) in expected grade A embryo count. Conclusion: There is a significant association between both the number of 2PN zygotes and cleavage day with the number of grade A embryos in both ZINB and ZIP regression models. The estimated coefficients are more plausible than values found in earlier studies using less relevant models.http://celljournal.org/journal/article/14378/downloadEmbryo ResearchAssisted Reproductive TechnologyCleavage StagePoisson DistributionZygote |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amir Almasi-Hashiani Azadeh Ghaheri Reza Omani Samani |
spellingShingle |
Amir Almasi-Hashiani Azadeh Ghaheri Reza Omani Samani Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model Cell Journal Embryo Research Assisted Reproductive Technology Cleavage Stage Poisson Distribution Zygote |
author_facet |
Amir Almasi-Hashiani Azadeh Ghaheri Reza Omani Samani |
author_sort |
Amir Almasi-Hashiani |
title |
Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model |
title_short |
Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model |
title_full |
Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model |
title_fullStr |
Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model |
title_full_unstemmed |
Determinants of The Grade A Embryos in Infertile Women; Zero-Inflated Regression Model |
title_sort |
determinants of the grade a embryos in infertile women; zero-inflated regression model |
publisher |
Royan Institute (ACECR), Tehran |
series |
Cell Journal |
issn |
2228-5806 2228-5814 |
publishDate |
2017-08-01 |
description |
Objective: In assisted reproductive technology, it is important to choose high quality embryos
for embryo transfer. The aim of the present study was to determine the grade A
embryo count and factors related to it in infertile women.
Materials and Methods: This historical cohort study included 996 infertile women. The
main outcome was the number of grade A embryos. Zero-Inflated Poisson (ZIP) regression
and Zero-Inflated Negative Binomial (ZINB) regression were used to model the count
data as it contained excessive zeros. Stata software, version 13 (Stata Corp, College Station,
TX, USA) was used for all statistical analyses.
Results: After adjusting for potential confounders, results from the ZINB model show that
for each unit increase in the number 2 pronuclear (2PN) zygotes, we get an increase of
1.45 times as incidence rate ratio (95% confidence interval (CI): 1.23-1.69, P=0.001) in the
expected grade A embryo count number, and for each increase in the cleavage day we get
a decrease 0.35 times (95% CI: 0.20-0.61, P=0.001) in expected grade A embryo count.
Conclusion: There is a significant association between both the number of 2PN zygotes
and cleavage day with the number of grade A embryos in both ZINB and ZIP regression
models. The estimated coefficients are more plausible than values found in earlier studies
using less relevant models. |
topic |
Embryo Research Assisted Reproductive Technology Cleavage Stage Poisson Distribution Zygote |
url |
http://celljournal.org/journal/article/14378/download |
work_keys_str_mv |
AT amiralmasihashiani determinantsofthegradeaembryosininfertilewomenzeroinflatedregressionmodel AT azadehghaheri determinantsofthegradeaembryosininfertilewomenzeroinflatedregressionmodel AT rezaomanisamani determinantsofthegradeaembryosininfertilewomenzeroinflatedregressionmodel |
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1724834775683825664 |