Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset
ObjectiveMany cancer patients complain about cognitive dysfunction. While cognitive deficits have been attributed to the side effects of chemotherapy, there is evidence for impairment at disease onset, prior to cancer-directed therapy. Further debated issues concern the relationship between self-rep...
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doaj-42d1b43db13145a3a7f6654061d779802020-11-24T22:00:06ZengFrontiers Media S.A.Frontiers in Psychology1664-10782019-11-011010.3389/fpsyg.2019.02584494691Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease OnsetJochen Kaiser0Jörg Dietrich1Miena Amiri2Isa Rüschel3Hazal Akbaba4Nonda Hantke5Klaus Fliessbach6Klaus Fliessbach7Bianca Senf8Christine Solbach9Christoph Bledowski10Institute of Medical Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesInstitute of Medical Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyInstitute of Medical Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyInstitute of Medical Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyInstitute of Medical Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyDepartment of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Centre, Bonn, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyDepartment of Psycho-Oncology, University Cancer Center, University Hospital Frankfurt am Main, Frankfurt am Main, GermanySenology Unit, Department of Gynecology and Obstetrics, University Hospital Frankfurt am Main, Frankfurt am Main, GermanyInstitute of Medical Psychology, Goethe University Frankfurt, Frankfurt am Main, GermanyObjectiveMany cancer patients complain about cognitive dysfunction. While cognitive deficits have been attributed to the side effects of chemotherapy, there is evidence for impairment at disease onset, prior to cancer-directed therapy. Further debated issues concern the relationship between self-reported complaints and objective test performance and the role of psychological distress.MethodWe assessed performance on neuropsychological tests of attention and memory and obtained estimates of subjective distress and quality of life in 27 breast cancer patients and 20 healthy controls. Testing in patients took place shortly after the initial diagnosis, but prior to subsequent therapy.ResultsWhile patients showed elevated distress, cognitive performance differed on a few subtests only. Patients showed slower processing speed and poorer verbal memory than controls. Objective and self-reported cognitive function were unrelated, and psychological distress correlated more strongly with subjective complaints than with neuropsychological test performance.ConclusionThis study provides further evidence of limited cognitive deficits in cancer patients prior to the onset of adjuvant therapy. Self-reported cognitive deficits seem more closely related to psychological distress than to objective test performance.https://www.frontiersin.org/article/10.3389/fpsyg.2019.02584/fullbreast cancercognitive functionspsychological distressattentionmemory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jochen Kaiser Jörg Dietrich Miena Amiri Isa Rüschel Hazal Akbaba Nonda Hantke Klaus Fliessbach Klaus Fliessbach Bianca Senf Christine Solbach Christoph Bledowski |
spellingShingle |
Jochen Kaiser Jörg Dietrich Miena Amiri Isa Rüschel Hazal Akbaba Nonda Hantke Klaus Fliessbach Klaus Fliessbach Bianca Senf Christine Solbach Christoph Bledowski Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset Frontiers in Psychology breast cancer cognitive functions psychological distress attention memory |
author_facet |
Jochen Kaiser Jörg Dietrich Miena Amiri Isa Rüschel Hazal Akbaba Nonda Hantke Klaus Fliessbach Klaus Fliessbach Bianca Senf Christine Solbach Christoph Bledowski |
author_sort |
Jochen Kaiser |
title |
Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset |
title_short |
Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset |
title_full |
Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset |
title_fullStr |
Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset |
title_full_unstemmed |
Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset |
title_sort |
cognitive performance and psychological distress in breast cancer patients at disease onset |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychology |
issn |
1664-1078 |
publishDate |
2019-11-01 |
description |
ObjectiveMany cancer patients complain about cognitive dysfunction. While cognitive deficits have been attributed to the side effects of chemotherapy, there is evidence for impairment at disease onset, prior to cancer-directed therapy. Further debated issues concern the relationship between self-reported complaints and objective test performance and the role of psychological distress.MethodWe assessed performance on neuropsychological tests of attention and memory and obtained estimates of subjective distress and quality of life in 27 breast cancer patients and 20 healthy controls. Testing in patients took place shortly after the initial diagnosis, but prior to subsequent therapy.ResultsWhile patients showed elevated distress, cognitive performance differed on a few subtests only. Patients showed slower processing speed and poorer verbal memory than controls. Objective and self-reported cognitive function were unrelated, and psychological distress correlated more strongly with subjective complaints than with neuropsychological test performance.ConclusionThis study provides further evidence of limited cognitive deficits in cancer patients prior to the onset of adjuvant therapy. Self-reported cognitive deficits seem more closely related to psychological distress than to objective test performance. |
topic |
breast cancer cognitive functions psychological distress attention memory |
url |
https://www.frontiersin.org/article/10.3389/fpsyg.2019.02584/full |
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