The Glomerular Filtration Barrier: Components and Crosstalk
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three...
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Series: | International Journal of Nephrology |
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doaj-42d2997bf6aa41709e4d8c0143f88c082020-11-25T00:50:38ZengHindawi LimitedInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/749010749010The Glomerular Filtration Barrier: Components and CrosstalkMadhav C. Menon0Peter Y. Chuang1Cijiang John He2Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USADivision of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USADivision of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USAThe glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents—the glomerular endothelial cell, the basement membrane and visceral epithelial cell (podocyte). Understanding the pathomechanisms of inherited and acquired human diseases as well as experimental injury models of this barrier have helped to unravel this interdependence. Key among the consequences of interference with the integrity of the glomerular filtration barrier is the appearance of significant amounts of proteins in the urine. Proteinuria correlates with kidney disease progression and cardiovascular mortality. With specific reference to proteinuria in human and animal disease phenotypes, the following review explores the roles of the endothelial cell, glomerular basement membrane, and the podocyte and attempts to highlight examples of essential crosstalk within this barrier.http://dx.doi.org/10.1155/2012/749010 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Madhav C. Menon Peter Y. Chuang Cijiang John He |
spellingShingle |
Madhav C. Menon Peter Y. Chuang Cijiang John He The Glomerular Filtration Barrier: Components and Crosstalk International Journal of Nephrology |
author_facet |
Madhav C. Menon Peter Y. Chuang Cijiang John He |
author_sort |
Madhav C. Menon |
title |
The Glomerular Filtration Barrier: Components and Crosstalk |
title_short |
The Glomerular Filtration Barrier: Components and Crosstalk |
title_full |
The Glomerular Filtration Barrier: Components and Crosstalk |
title_fullStr |
The Glomerular Filtration Barrier: Components and Crosstalk |
title_full_unstemmed |
The Glomerular Filtration Barrier: Components and Crosstalk |
title_sort |
glomerular filtration barrier: components and crosstalk |
publisher |
Hindawi Limited |
series |
International Journal of Nephrology |
issn |
2090-214X 2090-2158 |
publishDate |
2012-01-01 |
description |
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents—the glomerular endothelial cell, the basement membrane and visceral epithelial cell (podocyte). Understanding the pathomechanisms of inherited and acquired human diseases as well as experimental injury models of this barrier have helped to unravel this interdependence. Key among the consequences of interference with the integrity of the glomerular filtration barrier is the appearance of significant amounts of proteins in the urine. Proteinuria correlates with kidney disease progression and cardiovascular mortality. With specific reference to proteinuria in human and animal disease phenotypes, the following review explores the roles of the endothelial cell, glomerular basement membrane, and the podocyte and attempts to highlight examples of essential crosstalk within this barrier. |
url |
http://dx.doi.org/10.1155/2012/749010 |
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